Heads

  • Ángel Celdrán Uriarte
  • José María De Campos Gutiérrez
  • José Julio Zapatero Gaviria
  • Ignacio Muguruza Trueba

Research staff

  • Enriqueta Bernal Sánchez
  • Mariano Díaz Miguel Maseda
  • Raquel Gutiérrez González
  • Remedios López Serrano
  • Daniel Aguirre Mollehuanca

Trainee staff

  • Pablo Fernández Gómez-Escolar
  • Sonia Rivas Fidalgo

Technical staff and assistants

  • Valentinas De La Serna Ramírez

Other Support Staff

  • Mª José Reca Ramírez

Staff Research Associates

  • Natalia Barbero Bordallo. Hospital Universitario Rey Juan Carlos
  • Isabel Bustamante De Garnica. Hospital Universitario Rey Juan Carlos
  • Enrique Campos Villamiel. Hospital Universitario Rey Juan Carlos
  • Mª Rosario Noguero Meseguer. Hospital Universitario Rey Juan Carlos
  • Javier Pardo Moreno. Hospital Universitario Rey Juan Carlos

Collaborators

  • Jesús Manuel Culebras Fernández. Universidad de León



Main lines of research


Tumors of the central nervous system


- Malignant brain gliomas: New treatments for malignant brain gliomas

Participation in the EF-14 trial, an international, multicenter Phase III trial of transcranial electric fields and standard chemotherapy/radiation therapy as compared with standard treatments.

- New technologies for the surgical treatment of tumors of the nervous system

Use of fluorescence guided surgery with 5-ALA in the resection of malignant gliomas and its impact on tumor prognosis.

Design of a system for digital intraoperative visualization of the extension of non-malignant tumors of the nervous system (in collaboration with the Dept. of Optics at the Universidad Politécnica, Madrid).


Familial Neuro-Oncology:


- Von Hippel-Lindau disease

Clinical expression and genetic correlation.

Anatomical features that affect surgical therapy.

Expression of HIF and angiogenic factors in cultured hemangioblastomas as potential therapeutic targets, and clinical and histopathological correlations

Clinical and image tracking of endolymphatic sac tumor (with participation in an international multicenter study led by Dr. ML Bisgaard, Dept. of Cellular and Molecular Medicine, University of Copenhagen).


Clinical tracking and genetic correlations of pheochromocytomas and paragangliomas (in collaboration with Dr. M. Robledo, Endocrine Pathology Laboratory, CNIO)


- Neurofibromatosis

Clinical expression of neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis, with a particular focus on the epidemiology of tumors of the central nervous system.

Pathologies associated with the NF2 gene (in collaboration with Dr. J.A. Rey, Neuro-oncogenics Laboratory of the Hospital La Paz Institute for Health Research), as members of a research team participating in successive FIS projects.

- Tuberous Sclerosis Complex

Clinical expression, prevalence of disease manifestations, implementation of existing protocols for monitoring and studying the disease.


* Principal Investigators: José María de Campos Gutiérrez


Publications (2014)


Total number of Publications

Nº of Publications with IF

Accumulated IF

Average

IF

Nº of Publications (Q1)

(%) Q1

13

8

11,81

1,48

0

0,00%

1.

Cebrián A, Taron M, Sala N, Ardanaz E, Chirlaque MD, Larrañaga N, Redondo ML, Sánchez MJ, Gómez Del Pulgar T, Camps C, Rosell R, González CA, Lacal JC.Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.Clin Transl Oncol. 2014 Jan;16(1):107-12. doi: 10.1007/s12094-013-1080-7. Epub 2013 Jul 30..PubMed PMID:23896864

2.

Rodriguez-Cuellar E, Nevado García C, Casanova Duran V, Romero Simó M, Duran Poveda M, Ruiz Lopez P.Analysis of the quality of care in surgical treatment of colorectal cancer: national study. Follow-up results.Cir Esp. 2014 Jun-Jul;92(6):410-4. doi: 10.1016/j.ciresp.2013.09.017. Epub 2014 Jan 17. English, Spanish. Erratum in: Cir Esp. 2014 Dec;92(10):e67. .PubMed PMID:24439473

3.

García Vásquez C, Cortes Guiral D, Rivas Fidalgo S, Celdran Uriarte A.Gigantic gastric retention due to bulimic binge eating.Cir Esp. 2014 Jun-Jul;92(6):e33. doi: 10.1016/j.ciresp.2012.10.017. Epub 2014 Mar 15. English, Spanish. .PubMed PMID:24642029

4.

Marco-Martínez J, Barba-Martín R, Plaza-Canteli S, Canora-Lebrato J, Méndez-Baillón M, de Miguel-Yanes JM, Zapatero-Gaviria A.[Clostridium difficile infections in Spanish Internal Medicine departments during the period 2005-2010: the burden of the disease].Enferm Infecc Microbiol Clin. 2015 Jan;33(1):16-21. doi: 10.1016/j.eimc.2014.01.007. Epub 2014 Mar 27. Spanish. .PubMed PMID:24679445

5.

J. Lopez Torrecilla; A. Zapatero; I. Herruzo; F.A. Calvo; M.A. Cabeza; A. Palacios; A. Guerrero; A. Herva´s; P. Lara; B. Ludeña; E. del Cerro; G. Nagore; G. Sancho; J.L. Mengual; M. Mira; A. Mairiño; P. Samper; S. Perez; I. Castillo; J.C. Martinez Cedrés; E. Ferrer; S. Rodriguez; X. Maldonado; A. Gomez Caamaño; C. Ferrer and On behalf of the Grupo de Investigación GICOR-URONCOR-SEOR.Infrastructures, treatment modalities, and workload of radiation oncology departments in Spain with special attention to prostate cancer.Clin Transl Oncol. 2014 May;16(5):447-54. doi: 10.1007/s12094-013-1121-2. Epub 2013 Oct 25..PubMed PMID:24682792

6.

Arredondo J, González I, Baixauli J, Martínez P, Rodríguez J, Pastor C, Ribelles MJ, Sola JJ, Hernández-Lizoain JL.Tumor response assessment in locally advanced colon cancer after neoadjuvant chemotherapy.J Gastrointest Oncol. 2014 Apr;5(2):104-11. doi: 10.3978/j.issn.2078-6891.2014.006..PubMed PMID:24772338

7.

Arredondo J, Martínez P, Baixauli J, Pastor C, Rodríguez J, Pardo F, Rotellar F, Chopitea A, Hernández-Lizoáin JL.Analysis of surgical complications of primary tumor resection after neoadjuvant treatment in stage IV colon cancer.J Gastrointest Oncol. 2014 Apr;5(2):148-53. doi: 10.3978/j.issn.2078-6891.2014.015..PubMed PMID:24772343

8.

Gutiérrez-González R, Pérez-Zamarron A, Rodríguez-Boto G.Normal perfusion pressure breakthrough phenomenon: experimental models.Neurosurg Rev. 2014 Oct;37(4):559-67. doi: 10.1007/s10143-014-0549-3. Epub 2014 Apr 29..PubMed PMID:24777643

9.

Fernández E, Greger B, House PA, Aranda I, Botella C, Albisua J, Soto-Sánchez C, Alfaro A, Normann RA.Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects.Front Neuroeng. 2014;7:24. doi: 10.3389/fneng.2014.00024..PubMed PMID:25100989

10.

de Luis Daniel A Culebras Jesus M Aller Rocio Eiros-Bouza Jose María .Surgical infection and malnutrition.Nutr Hosp. 2014 Sep 1;30(3):509-13. doi: 10.3305/nh.2014.30.3.7702..PubMed PMID:25238824

11.

Culebras Jesús M .[Grande Covián and children malnutrition during the spanish civil war: comments on two classic papers published in "Revista Clínica Española" seventy years ago].Nutr Hosp. 2014 Sep 1;30(3):695-8. doi: 10.3305/nh.2014.30.3.7707. Spanish. .PubMed PMID:25238850

12.

Torres-Martin Miguel Lassaletta Luis Isla Alberto De Campos Jose M Pinto Giovanny R Burbano Rommel R Castresana Javier S Melendez Barbara Rey Juan A .Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue.Oncol Rep. 2014 Dec;32(6):2327-34. doi: 10.3892/or.2014.3526. Epub 2014 Oct 3..PubMed PMID:25333347

13.

Posada-González María Gómez-Ramírez Joaquín Luque-Ramírez Manuel Guijarro Mercedes Martín-Pérez Elena Rodríguez-Sánchez Ana García-Sanz Iñigo Larrañaga Eduardo .Nonfunctional Metastatic Parathyroid Carcinoma in the Setting of Multiple Endocrine Neoplasia Type 2A Syndrome.Surg Res Pract. 2014;2014:731481. doi: 10.1155/2014/731481. Epub 2014 Feb 20..PubMed PMID:25374962

Projects (2013)


1. "Pared abdominal donación" Investigador Principal Dr. Ángel Celdrán Uriarte.

Financiación privada. Ref. 30270/008.


2. "Donación" Investigador Principal Dr. Ángel Celdrán Uriarte.

Financiación privada. Ref. 30270/009.


Clinical trials (2013)


1. Clinical trial: "Ensayo prospectivo multicéntrico de NOVOTTF-100ª en combinación con TEMOZOLOMIDA comparado con TEMOZOLOMIDA en monoterapia en pacientes con GBM de reciente diagnóstico". (NºEUDRACT: NA Clinical trial Fase III Multicéntrico Internacional). Investigador Principal: J. M de Campos Gutiérrez.