Research into New Therapies

Heads

• Orencio Bosch Esteva
• Carlos Cenjor Español (Associate Professor, UAM)
• Ángeles Franco López
• Damián García Olmo (Professor, UAM)
• Ignacio Jiménez-Alfaro Morote
• Juan Carlos Porres Cubero (Professor, UAM)
• Margarita Varela Morales

Professional investigator

• Nicolás Alejandre Alba
• Mayte Ariño Gutiérrez
• María Benavides Gabernet
• Raúl Cortez Castillo
• Sonia Durán Poveda
• Alberto Encinas Vicente
• Mariano García Arranz
• Raquel García Castellanos
• Blanca García Sandoval
• Ana González Bueno
• Agustina González Guirado
• Héctor Guadalajara Labajo
• María Dolores Herreros Marcos
• Isabel López Molina
• Mª Jesús Martín Relloso
• Óscar Martínez Pérez
• Cristina Ordóñez González
• Antonio Pérez Higueras
• Benjamín Pérez Villacastín
• Francisco Javier Plaza Arranz
• Benjamín Polo Lorduy
• Jorge Polo Sabau
• Guillermo Fernández Sanz
• Carmen Rodríguez-Bermejo Guijo
• Jaime Sanabria Brassat
• Paloma Sánchez-Fayos Calabuig
• Ignacio Tapias Elías
• Marta Tomás Mallebrera
• José Miguel Villacampa Auba
• Pablo García-Camba Varela
• Marta Agreda Chinea
• Daniel Calero Baron
• Rocío Calvo Hernández
• Irune Cariñanos Prado
• Sergio Farrais Villalba
• Cristina Hoyuela Vigil
• Manuel Vicente Milán Pilo
• Marta Moran Ortiz de Solorzano
• Jorge Antonio Núñez Otero
• Mª José Romero Valle
• Andrés L; Varela Silva
• Paula Maria Vázquez de Parga Coca
• Susana Olmedillas López
• Carlos Pastor Idoate

Trainee staff

Technical Staff

• Mª Luz Vega Clemente

Other Support Staff

• Ángeles Heredero Jung
• Gloria Ortiz Miluy
• Verónica Pérez Abadía

Staff Research Associates

• Mª Esther Arranz Márquez. Hospital Universitario Rey Juan Carlos
• Iván Carabaño Guado. Hospital Universitario Rey Juan Carlos
• Manuel Durán Poveda. Hospital Universitario Rey Juan Carlos
• Luis Ricardo Gotuzzo Altez. Hospital Universitario Rey Juan Carlos
• José Granel Navarro. Hospital Universitario Rey Juan Carlos
• Raimundo Gutiérrez Fonseca. Hospital Universitario Rey Juan Carlos
• María Antonia Huertas Velasco. Hospital Universitario Rey Juan Carlos
• Elena Jarrin Hernández. Hospital Universitario Rey Juan Carlos
• Santos Francisco Jiménez de los Galanes Marchán. Hospital Universitario Infanta Elena
• Ana María Martín Casado. Hospital Universitario Rey Juan Carlos
• Teresa Millas Gómez. Hospital Universitario Rey Juan Carlos
• Guillermo Payeras Llodrá. Hospital Universitario Rey Juan Carlos
• Lorena Pingarrón Martín. Hospital Universitario Rey Juan Carlos
• Francisco Álvaro Cogolludo Perez
• Álvaro Sanchez-Barrueco
• Francisco Guerra Blanco, belong to Otolaryngology Service and implicated in clinical trials

Main lines of research

Adult stem cell research:

Mariano GarcíaThis line of research focuses on addressing clinical conditions that do not respond adequately to treatment through the generation of experimental models and subsequent treatment by cell therapy. Ongoing research includes the generation of abdominal aortic aneurysms in a porcine model and stabilization of the aneurysm sac using mesenchymal stem cells (MSCs). Another important objective of this research is to improve the systems used to isolate stem cells of different origins, study their characterization, differentiation, and combination with various biomaterials, and to perform toxicity studies and improve the storage and transport of stem cells. Finally, a third line of research focuses on biosafety studies and MSCs, with a particular focus on cell behavior in tumor environments.

* Principal Investigator: Mariano García

Treatment of patients with stem cells

This line of research seeks to translate to clinical settings the results seen in studies of stem cells in experimental models and clinical trials and after their administration for compassionate use. One example of this line of research, led by the IIS-FJD, is the Phase III clinical trial for the treatment of complex perianal fistula using mesenchymal stem cells derived from adipose tissue.

Genometastasis

Damián García OlmoGenometastasis was first described in 2001 by Professor García Olmo and can be broadly defined as the transfer of tumoral DNA through the plasma/serum, promoting the formation of tumors and the development of metastasis. This line of research includes an ongoing FIS project entitled "High-capacity sequencing of exomes of free DNA in the plasma of patients with colorectal cancer ("liquid biopsy") and their role in the metastatic process". This involves the application of sequencing technology at the genomic scale to freely circulating DNA in plasma (liquid biopsy) in order to identify markers that may predict the development of metastasis in colorectal cancer.

This line of work attempts to elucidate the mechanisms underlying colorectal cancer and its evolution through simple, minimally invasive blood tests, which could be of significant prognostic value and have important implications for personalized medicine.

In parallel we are conducting studies to establish a relationship of prognostic value between intestinal microbiota and colorectal cancer by analyzing bacterial DNA and investigating the possible transforming ability of fecal DNA.

* Principal Investigator: Damián García Olmo

Line of research regarding Ophtalmology

Jiménez AlfaroDr. Jiménez-Alfaro has collaborated with the Daza de Valdes Institute of Optics at the CSIC since 2000 as part of the research group led by Dr. Susana Marcos. The main lines of research lines of the group are the study of the optical quality of the visual system after surgical procedures of the cornea and crystalline lens, with a particular focus on optical aberrations of intraocular lenses and the development of new techniques to study these aberrations. More recent work has focused on the study of accommodation and presbyopia.

Dr. Jiménez-Alfaro is the PI and Dr. Alejandre Alba is the head scientist for European project ERC-2011-AdG-294099, entitled "Bio-inspired optical correction of presbyopia" (PRESBYOPIA), which seeks to better understand the mechanism of accommodation in humans and in certain animals, to develop new techniques to study accommodation in vivo and in vitro, and to propose new solutions to correct presbyopia based on the findings obtained. We are also participating in 2 other joint research projects, one focused on the study of accommodative intraocular lenses (Dr. Durán Poveda) and another dedicated to the study of keratoconus and intracorneal ring implantation (Dr. Alejandre Alba).

* Principal Investigator: Ignacio Jiménez-Alfaro

Line of research regarding retinal diseases

Dr. Garcia Sandoval has been working for the past 10-15 years with the Department of Genetics studying inherited degenerative retinopathy. Dr. Tapias Elíes and Dr. López Molina are also involved in this line of research. Dr. Ariño Gutierrez is conducting a study of corneal dystrophies, also in collaboration with the Department of Genetics.

* Principal Investigator: Blanca García Sandoval and Mayte Ariño Gutiérrez

Line of research

Dr. Fernandéz Sanz, who is currently completing his training abroad, focuses his research on the study of age-associated macular degeneration, diabetic retinopathy, and intraocular inflammation.

* Principal Investigator: Guillermo Fernández Sanz

Line of research

Dr. Rodríguez-Bermejo Guijo conducts studies on different surgical techniques and drainage devices used in the treatment of glaucoma.

* Principal Investigator: Carmen Rodríguez-Bermejo Guijo

Use of microscrews in orthodontic anchorage

Margarita García y Pablo Varela

The introduction of microscrews as a method of skeletal anchorage in orthodontics has heralded a paradigm shift in our specialty, expanding the available options for the management of malocclusions and facial deformities. However, many of the possible applications of this new technology, which is undergoing continuous development, remain to be discovered. Dr. García-Camba was invited as a visiting orthodontist by Prof. Kyung, South Korea, one of the foremost experts in the use of skeletal anchorage techniques in both research and clinical settings

* Principal Investigator: Pablo García-Camba

Orthodontic traction of included teeth

Severe tooth eruption disturbances constitute a diverse range of complex conditions that require interdisciplinary diagnosis and treatment involving radiologists, maxillofacial surgeons, and dentists/stomatologists. The genetic relationship between eruptive disorders and tooth agenesis and its association with various syndromes is a particularly interesting field of research. The first doctoral thesis on maxillary canines was published by our service in 1996. Putative genetic associations between tooth agenesis and eruptive deviation of the second premolar is the research focus of one of our ongoing projects, and the subject of a doctoral thesis.

* Principal Investigator: Margarita Varela Morales and Pablo García-Camba

Relationship between dental trauma and maxillofacial skeletal structure

Given the high prevalence of dental trauma in children and adolescents, prevention is a priority within our specialty. It is therefore essential to define the risk factors, which include sagittal skeletal characteristics.

* Principal Investigator: Margarita Varela Morales

Publications (2014)

Total number of Publications	Nº of Publications with IF	Accumulated IF	Average IF	Nº of Publications (Q1)	(%) Q1
57	36	146,74	4,32	25	69,44%

1. Llames Sara Recuero Ignacio Romance Ana García Eva Peña Ignacio Del Valle Alvaro Fernández Meana Alvaro Larcher Fernando Del Río Marcela .Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia.Cleft Palate Craniofac J. 2014 Mar;51(2):246-51. doi: 10.1597/12-245. Epub 2013 Jul 23..PubMed PMID:23879858

2. Gostynski Antoni Llames Sara García Marta Escamez María J Martinez-Santamaria Lucía Nijenhuis Miranda Meana Alvaro Pas Hendri H Larcher Fernando Pasmooij Anna M G Jonkman Marcel F Del Rio Marcela .Long-term survival of type XVII collagen revertant cells in an animal model of revertant cell therapy.J Invest Dermatol. 2014 Feb;134(2):571-4. doi: 10.1038/jid.2013.308. Epub 2013 Jul 24. .PubMed PMID:23884316

3. Saura Pedro Saura Javier Pérez-Higueras Antonio Martínez-Galdámez Mario .Direct transforaminal Onyx embolization of intracranial dural arteriovenous fistulas: technical note and report of five cases.J Neurointerv Surg. 2014 Sep;6(7):500-4. doi: 10.1136/neurintsurg-2013-010890. Epub 2013 Sep 2..PubMed PMID:23999130

4. Saiz-Ladera C Lara M F Garín M Ruiz S Santos M Lorz C García-Escudero R Martínez-Fernández M Bravo A Fernández-Capetillo O Segrelles C Paramio J M .p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.Oncogene. 2014 Sep 11;33(37):4599-612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14..PubMed PMID:24121270

5. Kovacs FM, Arana E, Royuela A, Estremera A, Amengual G, Asenjo B, Sarasíbar H, Galarraga I, Alonso A, Casillas C, Muriel A, Martínez C, Abraira V..Disc degeneration and chronic low back pain: an association which becomes nonsignificant when endplate changes and disc contour are taken into account.Neuroradiology. 2014 Jan;56(1):25-33. doi: 10.1007/s00234-013-1294-y. Epub 2013 Nov 5..PubMed PMID:24190653

6. Chiaverini C Charlesworth A Fernandez A Barbarot S Bessis D Bodemer C Bursztejn A-C Cobo A-M Del Rio M D'Incan M Labrèze C Langlet C Mazereeuw J Miquel J Vabres P Meneguzzi G Lacour J-P .Aplasia cutis congenita with dystrophic epidermolysis bullosa: clinical and mutational study.Br J Dermatol. 2014 Apr;170(4):901-6. doi: 10.1111/bjd.12741..PubMed PMID:24252097

7. Gostynski Antoni Pasmooij Anna M G Del Rio Marcela Diercks Gilles F Pas Hendri H Jonkman Marcel F .Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen.Exp Dermatol. 2014 Feb;23(2):130-2. doi: 10.1111/exd.12304..PubMed PMID:24330315

8. Arranz-Marquez E, Fatela-Cantillo B, Figueroa M, Teus MA.[Late onset lens particle glaucoma in Marfan syndrome].Arch Soc Esp Oftalmol. 2015 Jan;90(1):40-3. doi: 10.1016/j.oftal.2013.11.011. Epub 2014 Jan 1. Spanish. .PubMed PMID:24388607

9. Navarro S Moleiro V Molina-Estevez F J Lozano M L Chinchon R Almarza E Quintana-Bustamante O Mostoslavsky G Maetzig T Galla M Heinz N Schiedlmeier B Torres Y Modlich U Samper E Río P Segovia J C Raya A Güenechea G Izpisua-Belmonte J C Bueren J A, .Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy.Stem Cells. 2014 Feb;32(2):436-46. doi: 10.1002/stem.1586..PubMed PMID:24420904

10. Oleñik A.Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.Clin Ophthalmol. 2014;8:169-76. doi: 10.2147/OPTH.S54658. Epub 2014 Jan 6..PubMed PMID:24421636

11. Bracke Stefanie Carretero Marta Guerrero-Aspizua Sara Desmet Eline Illera Nuria Navarro Manuel Lambert Jo Del Rio Marcela .Targeted silencing of DEFB4 in a bioengineered skin-humanized mouse model for psoriasis: development of siRNA SECosome-based novel therapies.Exp Dermatol. 2014 Mar;23(3):199-201. doi: 10.1111/exd.12321..PubMed PMID:24428418

12. Culebras JM, García de Lorenzo Y Mateos A.[In process citation].Nutr Hosp. 2014 Jan 1;29(1):1-2. doi: 10.3305/nh.2014.29.1.7258. Spanish. .PubMed PMID:24483955

13. Segrelles Carmen García-Escudero Ramón Garín Maria I Aranda Juan F Hernández Pilar Ariza José M Santos Mirentxu Paramio Jesús M Lorz Corina .Akt signaling leads to stem cell activation and promotes tumor development in epidermis.Stem Cells. 2014 Jul;32(7):1917-28. doi: 10.1002/stem.1669..PubMed PMID:24504902

14. Cantero Cid R Salinas Gómez J García Olmo D .How to place a seton and prevent it slipping: mission impossible?Tech Coloproctol. 2014 Jun;18(6):603. doi: 10.1007/s10151-013-1118-4. Epub 2014 Feb 14. .PubMed PMID:24526396

15. Pérez-Merino P, Birkenfeld J, Dorronsoro C, Ortiz S, Durán S, Jiménez-Alfaro I, Marcos S.Aberrometry in patients implanted with accommodative intraocular lenses.Am J Ophthalmol. 2014 May;157(5):1077-89. doi: 10.1016/j.ajo.2014.02.013. Epub 2014 Feb 14..PubMed PMID:24531019

16. Kiritsi Dimitra Garcia Marta Brander Renske Has Cristina Meijer Rowdy Jose Escámez Maria Kohlhase Jürgen van den Akker Peter C Scheffer Hans Jonkman Marcel F del Rio Marcela Bruckner-Tuderman Leena Pasmooij Anna M G .Mechanisms of natural gene therapy in dystrophic epidermolysis bullosa.J Invest Dermatol. 2014 Aug;134(8):2097-104. doi: 10.1038/jid.2014.118. Epub 2014 Feb 27..PubMed PMID:24577406

17. Tremblay Jacques P Aartsma-Rus Annemieke Bogdanove Adam Ferreira Marcello Bossois Bueren Juan Huard Johnny .Development of a web course on gene therapy by the international consortium of gene therapy.Mol Ther. 2014 Mar;22(3):482. doi: 10.1038/mt.2014.11. .PubMed PMID:24584076

18. Arriola-Villalobos P, Alejandre-Alba N.[Should we reduce the number of ophthalmology residents in Spain?].Arch Soc Esp Oftalmol. 2014 Feb;89(2):45-7. doi: 10.1016/j.oftal.2014.01.004. Spanish. .PubMed PMID:24594226

19. Sendagorta Elena Herranz Pedro Guadalajara Hector Bernardino Jose Ignacio Viguer Jose María Beato María José García-Olmo Damian Peña Jose María .Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.Dis Colon Rectum. 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095..PubMed PMID:24608304

20. Martínez-Galdámez M, Saura P, Saura J, Muñiz J, Albisua J, Pérez-Higueras A.Transvenous Onyx embolization of a subependymal deep arteriovenous malformation with a single drainage vein: technical note.J Neurointerv Surg. 2014 Apr 1;6(3):e20. doi: 10.1136/neurintsurg-2012-010603.rep. Epub 2013 Apr 10..PubMed PMID:24610142

21. Ahumada F, Pérez D, de Górgolas M, Alvarez B, Ríos A, Sánchez A, Villacampa J.Subacute histoplasmosis with focal involvement of the epiglottis: importance of differential diagnosis.Case Rep Otolaryngol. 2014;2014:235975. doi: 10.1155/2014/235975. Epub 2014 Feb 5..PubMed PMID:24653845

22. Palfy JA, Tomás M, Farré J, Navas MA, Navarro F, Orejas M, Franco A.Pure right ventricular infarction resulting from coronary ectasia: importance of diagnostic imaging.Can J Cardiol. 2014 Apr;30(4):464.e9-11. doi: 10.1016/j.cjca.2013.12.018. Epub 2013 Dec 30..PubMed PMID:24680175

23. Fernández-Pérez GC, Franco López A, García Fernández MA, Corral de la Calle MA, Encinas de la Iglesia J, Velasco Casares M.[Left ventricular systolic function: how to understand it and analyze it].Radiologia. 2014 Nov-Dec;56(6):505-14. doi: 10.1016/j.rx.2013.09.006. Epub 2014 Apr 4. Spanish. .PubMed PMID:24703986

24. Puig-Butille Joan Anton Escámez María José Garcia-Garcia Francisco Tell-Marti Gemma Fabra Àngels Martínez-Santamaría Lucía Badenas Celia Aguilera Paula Pevida Marta Dopazo Joaquín del Río Marcela Puig Susana .Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer.Oncotarget. 2014 Mar 30;5(6):1439-51..PubMed PMID:24742402

25. Viteri-Ramírez G, Alonso-Burgos A, Simon-Yarza I, Rotellar F, Herrero JI, Bilbao JI.Hepatic venous outflow obstruction after transplantation: outcomes for treatment with self-expanding stents.Radiologia. 2015 Jan-Feb;57(1):56-65. doi: 10.1016/j.rx.2013.09.010. Epub 2014 Apr 29. English, Spanish. .PubMed PMID:24784003

26. Jimeno Rebeca Leceta Javier Martínez Carmen Gutiérrez-Cañas Irene Carrión Mar Pérez-García Selene Garín Marina Mellado Mario Gomariz Rosa P Juarranz Yasmina .Vasoactive intestinal peptide maintains the nonpathogenic profile of human th17-polarized cells.J Mol Neurosci. 2014 Nov;54(3):512-25. doi: 10.1007/s12031-014-0318-3. Epub 2014 May 8..PubMed PMID:24805298

27. Granell Jose Mendez-Benegassi Ivan Millas Teresa Garrido Laura Gutierrez-Fonseca Raimundo .Transoral Robotic Surgery: Step-by-Step Radical Tonsillectomy.Case Rep Otolaryngol. 2014;2014:497528. doi: 10.1155/2014/497528. Epub 2014 Apr 6..PubMed PMID:24808963

28. Oleñik A, Mahillo-Fernández I, Alejandre-Alba N, Fernández-Sanz G, Pérez MA, Luxan S, Quintana S, Martínez de Carneros Llorente A, García-Sandoval B, Jiménez-Alfaro I.Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.Clin Ophthalmol. 2014;8:831-6. doi: 10.2147/OPTH.S62470..PubMed PMID:24812490

29. Rio P, Baños R, Lombardo A, Quintana-Bustamante O, Alvarez L, Garate Z, Genovese P, Almarza E, Valeri A, Díez B, Navarro S, Torres Y, Trujillo JP, Murillas R, Segovia JC, Samper E, Surralles J, Gregory PD, Holmes MC, Naldini L, Bueren JA.Targeted gene therapy and cell reprogramming in Fanconi anemia.EMBO Mol Med. 2014 May 23;6(6):835-48. doi: 10.15252/emmm.201303374..PubMed PMID:24859981

30. Leon-Rico D, Aldea M, Sanchez R, Segovia JC, Weiss LA, Hidalgo A, Bueren JA, Almarza E.Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow.Stem Cells. 2014 Oct;32(10):2794-8. doi: 10.1002/stem.1762..PubMed PMID:24906078

31. Santos-Bueso E, Fernández-Jacob MC, Asorey-García A, Sánchez-Jacob E, Cerván-López I, Jiménez-Carmona S, Rodríguez-Bermejo C, Gutiérrez-Ortiz C, García-Medina JJ, Arteaga-Sánchez A, Vinuesa-Silva I, Vinuesa-Silva JM, García-Sánchez J.[Ophthalmology, history and humanities].Arch Soc Esp Oftalmol. 2014 Jun;89(6):213-5. doi: 10.1016/j.oftal.2014.04.025. Spanish. .PubMed PMID:24929273

32. Jarrín E, Cabarga-Nozal C, Almendral A, Muñoz-Negrete FJ.Peripheral yttrium aluminium garnet (YAG) iridotomy versus phacoemulsification in primary angle closure: prospective comparative study.Arch Soc Esp Oftalmol. 2014 Sep;89(9):352-60. doi: 10.1016/j.oftal.2014.04.007. Epub 2014 Jun 20. English, Spanish. .PubMed PMID:24954413

33. Liu GH, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, Del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR, Izpisua Belmonte JC.Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.Nat Commun. 2014 Jul 7;5:4330. doi: 10.1038/ncomms5330..PubMed PMID:24999918

34. Pulecio Julian Nivet Emmanuel Sancho-Martinez Ignacio Vitaloni Marianna Guenechea Guillermo Xia Yun Kurian Leo Dubova Ilir Bueren Juan Laricchia-Robbio Leopoldo Izpisua Belmonte Juan Carlos .Conversion of human fibroblasts into monocyte-like progenitor cells.Stem Cells. 2014 Nov;32(11):2923-38. doi: 10.1002/stem.1800..PubMed PMID:25175072

35. de Miguel-Yanes JM, Méndez-Bailón M, Marco-Martínez J, Zapatero-Gaviria A, Barba-Martín R.Absence of interaction of diabetes mellitus with chronic kidney disease on mortality in acute heart failure.Ren Fail. 2014 Nov;36(10):1536-40. doi: 10.3109/0886022X.2014.958974. Epub 2014 Sep 11..PubMed PMID:25211320

36. Barco R Encinas C Valencia M Carrascal M T García-Arranz M Antuña S .[Use of adipose-derived stem cells in an experimental rotator cuff fracture animal model].Rev Esp Cir Ortop Traumatol. 2015 Jan-Feb;59(1):3-8. doi: 10.1016/j.recot.2014.07.008. Epub 2014 Sep 18. Spanish. .PubMed PMID:25242729

37. Millas Teresa Granell Jose Garrido Laura Mendez-Benegassi Ivan Gutierrez-Fonseca Raimundo .Transoral robotic approach for laryngeal schwannoma.Head Neck. 2014 Oct 28. doi: 10.1002/hed.23904. [Epub ahead of print].PubMed PMID:25352229

38. Georgiev-Hristov T Tone-Villanueva F Trébol J Ayuela-García S Castell-Gómez J T García-Olmo D .[Coloduodenal fistula in a patient with Crohn's disease].Rev Esp Enferm Dig. 2014 Jun;106(6):426-7. .PubMed PMID:25361456

39. Jiménez-Fuertes M Durán-Poveda M García-Olmo D .Pancreaticopleural fistula: An unusual cause of persistent pleural effusion.Rev Esp Enferm Dig. 2014 Jun;106(6):428-9. .PubMed PMID:25361457

40. Duarte Blanca Miselli Francesca Murillas Rodolfo Espinosa-Hevia Luis Cigudosa Juan Cruz Recchia Alessandra Del Río Marcela Larcher Fernando.Long-term skin regeneration from a gene-targeted human epidermal stem cell clone.Mol Ther. 2014 Nov;22(11):1878-80. doi: 10.1038/mt.2014.187. .PubMed PMID:25365983

41. Mora Maria Valencia Antuña Samuel Antuña Arranz Mariano García Carrascal Maria Teresa Barco Raúl .Application of adipose tissue-derived stem cells in a rat rotator cuff repair model.Injury. 2014 Oct;45 Suppl 4:S22-7. doi: 10.1016/S0020-1383(14)70006-3..PubMed PMID:25384471

42. Martín-Mateos Pedro Crespo-Garcia Sergio Ruiz-Llata Marta Lopez-Fernandez José Ramón Jorcano José Luis Del Rio Marcela Larcher Fernando Acedo Pablo .Remote diffuse reflectance spectroscopy sensor for tissue engineering monitoring based on blind signal separation.Biomed Opt Express. 2014 Sep 1;5(9):3231-7. doi: 10.1364/BOE.5.003231..PubMed PMID:25401034

43. Jimeno Rebeca Gomariz Rosa P Garín Marina Gutiérrez-Cañas Irene González-Álvaro Isidoro Carrión Mar Galindo María Leceta Javier Juarranz Yasmina .The pathogenic Th profile of human activated memory Th cells in early rheumatoid arthritis can be modulated by VIP.J Mol Med (Berl). 2015 Apr;93(4):457-67. doi: 10.1007/s00109-014-1232-4. Epub 2014 Nov 28..PubMed PMID:25430993

44. Álvarez Fernández B, Rico Pajares M, Ares Mateos G, Pérez Grande MC, Carabaño Aguado I.Sistemas de ventilación no invasiva de alto flujo en neonatología: revisión y aproximación a su utilización en hospitales de la Comunidad de Madrid. Acta Pediatr Esp2014.PubMed PMID:0

45. Echeverría Fernández M, Herrero Álvarez M, Carabaño Aguado I.Hábitos de merienda en escolares de nuestro medio. Estudio HABIMER Plus.Rev Pediatr Aten Primaria.2014.PubMed PMID:0

46. Álvarez Fernández B, Pérez Grande MC, Ares Mateos G, Jiménez González E, Alonso Benavente AJ, Expósito Jiménez D..Artritis séptica de hombro por E. coli en un prematuro.Rev Pediatr Aten Prim2014.PubMed PMID:0

47. Domínguez-Mompell Micó, R., De la Cruz Fernández, C., Marcianes Moreno, M., Morón Duelo, R., García-Camba Varela, P., Varela Morales, M. .Incisivos en pala: frecuencia en pacientes ortodóncicos de diversas etniasCient. Dent. 2014.PubMed PMID:0

48. Margarita Varela.Incisivos centrales superiores permanentes incluidos: análisis retrospectivo de 35 pacientes tratados con ortodonciaRev Esp Ortod2014.PubMed PMID:0

49. Gonzalez M, Pérez E, Diaz Y, De Felipe O, Rodriguez JM.Secuencia anemia policitemia espontánea. Presentación de un caso y revisión de la bibliografia Toko - Ginecología Práctica2014.PubMed PMID:0

50. Valencia Mora M, Antuña Antuña S, Garcìa Arranz M, Carrascal MT, Barco R..Application of adipose tissue-derived stem cells in a rat rotator cuff repair model.Injury. 2014 Oct;45 Suppl 4:S22-7. doi: 10.1016/S0020-1383(14)70006-3..PubMed PMID:25384471

51. Salazar-Álvarez AE, Riera-del-Moral LF, Garcìa-Arranz M, Alvarez-Garcìa J, Concepción-Rodriguez NA, Riera-de-Cubas L..Use of platelet-rich plasma in the healing of chronic ulcers of the lower extremity.Actas Dermosifiliogr. 2014 Jul-Aug;105(6):597-604. doi: 10.1016/j.ad.2013.12.011. Epub 2014 Mar 12. English, Spanish. .PubMed PMID:24630241

52. Sendagorta E, Herranz P, Guadalajara H, Bernardino JI, Viguer JM, Beato MJ, Garcìa-Olmo D, Peña JM..Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.Dis Colon Rectum. 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095..PubMed PMID:24608304

53. Pérez-Merino P, Birkenfeld J, Dorronsoro C, Ortiz S, Durán S, Jiménez-Alfaro I, Marcos S. .Aberrometry in patients implanted with accommodative intraocular lenses.Am J Ophthalmol. 2014 May;157(5):1077-89. doi: 10.1016/j.ajo.2014.02.013. Epub 2014 Feb 14..PubMed PMID:24531019

54. Cantero Cid R, Salinas Gómez J, Garcìa Olmo D..How to place a seton and prevent it slipping: mission impossible?Tech Coloproctol. 2014 Jun;18(6):603. doi: 10.1007/s10151-013-1118-4. Epub 2014 Feb 14. No abstract available. .PubMed PMID:24526396

55. Barba-Recreo P, Del Castillo Pardo de Vera JL, Garcìa-Arranz M, Yébenes L, Burgueño M..Zoledronic acid - related osteonecrosis of the jaws. Experimental model with dental extractions in rats.J Craniomaxillofac Surg. 2014 Sep;42(6):744-50. doi: 10.1016/j.jcms.2013.11.005. Epub 2013 Nov 15..PubMed PMID:24342733

56. Pérez-Merino P, Ortiz S, Alejandre N, de Castro A, Jimenez-Alfaro I, Marcos S.Ocular and optical coherence tomography-based corneal aberrometry in keratoconic eyes treated by intracorneal ring segments.Am J Ophthalmol. 2014 Jan;157(1):116-127.e1. doi: 10.1016/j.ajo.2013.08.017. Epub 2013 Oct 22..PubMed PMID:24161248

57. Marcos S, Ortiz S, Pérez-Merino P, Birkenfeld J, Duran S, Jimenez-Alfaro I. .Three-dimensional evaluation of accommodating intraocular lens shift and alignment in vivo.Ophthalmology. 2014 Jan;121(1):45-55. doi: 10.1016/j.ophtha.2013.06.025. Epub 2013 Aug 12..PubMed PMID:23948466

Projects and Courses (2013)

1. "Evaluación de la receptividad endometrial por medio de estudio in vitro de biomarcadores tisulares en pacientes tratadas con fecundación in vitro. Estudio de cohortes prospectivo de evaluación de prueba diagnóstica". Investigadora Principal Dra. M.C Hernández Rodríguez.
Financiación privada 6759/001.
2. "Bio-inspired optical correction of Presbyopia (PRESBYOPIA)". Investigador Principal Dr. I. Fenández-Alfaro Morote.
Proyecto Público competitivo PIC 49/2011 PRESBYOPIA.

3. "Proyecto cornea". Investigador Principal Dr. I. Fenández-Alfaro Morote.
Financiación privada 4269/002.

4. "Curso de Cirugía de implante coclear y disección en hueso temporal" Investigador Principal Dr. C. J. Cenjor Español.
Financiación privada 4021/004.

5. "I Curso de disección anatomoquirúrgica de hueso temporal (nivel básico)" Investigador Principal Dr. C. J. Cenjor Español.
Financiación privada 4021/001.

6. "Curso de disección anatomoquirúrgica de senos paranasales (nivel básico)" Investigador Principal Dr. C. J. Cenjor Español.
Financiación privada 4021/002.

7. "Cursos teóricos y prácticos de utilización de material para tratamiento neuroendovascular". Investigador Principal Dr. A. Pérez Higueras.
Financiación privada 4254/006.

8. "Cursos teóricos y prácticos de utilización de material de embolización". Investigador Principal Dr. A. Pérez Higueras.
Financiación privada 4254/005 y 4254/007.

9. "Entrenamiento en el manejo de material de neurorradiología intervencionista". Investigador Principal Dr. A. Pérez Higueras.
Financiación privada 4254/008.

10. "Redes de Investigación Cooperativa en Salud (RETICS) para los años 2013, 2014, 2015 y 2016". Investigador principal: Prof. D. García Olmo.
Proyecto Público competitivo RD12/0019/0035.

11. "Tratamiento de los aneurismas de aorta abdominal mediante células madre mesenquimales derivadas del tejido adiposo en un modelo porcino". Investigador principal: Dr. M. García Arranz.
Proyecto Público competitivo PI11/00116.

12. "Sequencing of exomes in plasma of colorectal cancer patients ("liquid biopsy"). Relationship with metastasis development". Investigador principal: Prof. D. García Olmo.
Proyecto Público competitivo FISS 2013.

13. "A new generation of cells more safety and efficacy " nvestigador principal: Prof. D. García Olmo.
Proyecto Público competitivo P2010/BMD-2420.

Clinical trials and Observational studies (2013)

1. Clinical trial: "Ensayo Fase IIIb, aleatorizado, doble ciego, de grupos paralelos, multicéntrico, para comparar el riesgo de muerte cardiovascular, infarto de miocardio e ictus isquémico en pacientes con enfermedad arterial periférica establecida, tratados con Ticagrelor" (NºEUDRACT: 2011-004616-36 Clinical trial Fase IIIb Multicéntrico Internacional). Investigador Principal: A.B. Arribas Díaz.

2. Clinical trial: "Implantes cocleares nucleus ® para pacientes con acúfenos graves e hipoacusia asimétrica" Investigador Principal: C.J. Cenjor Español.

3. Clinical trial: "Estudio aleatorizado, doble ciego, fase II, controlado con placebo, con dos brazos para evaluar la eficacia y seguridad de DUPILUMAB en pacientes con poliposis nasal bilateral y síntomas crónicos de sinusitis" (NºEUDRACT2013-001803-35 Clinical trial Fase II Multicéntrico Internacional). Investigador Principal: C.J. Cenjor Español.

4. Clinical trial: "Estudio para evaluar la seguridad e inmunogenicidad de la vacuna Herpes Zoster GSK1437173A de GSK BILOGICALS en adultos de 18 años de edad y mayores con neoplasias hematológicas" (NºEUDRACT 2012-003438-18 Clinical trial Fase III Multicéntrico Internacional). Investigador Principal: T. del Campo Balsa.

5. Clinical trial: "Comparación de LATANOPROST 50 g/ml colirio vs XALATAN colirio en el tratamiento de Glaucoma de ángulo abierto: Un estudio clínico abierto, randomizado" (NºEUDRACT 2011-002601-30 Clinical trial Fase III). Investigador Principal: J. Herrera Pereiro.

6. Clinical trial: "Ensayo piloto para evaluar la seguridad y el efecto de SYL1001 en pacientes con dolor ocular" (NºEUDRACT 2012-001177-93 Clinical trial Fase II Multicéntrico). Investigador Principal: I. Jiménez-Alfaro Morote.

7. Clinical trial: "Disfunción de las glándulas de meibomio y uso de ácidos grasos omega 3 como adyuvantes en el tratamiento: Clinical trial doble ciego y aleatorizado" (NºEUDRACT 2011-005310-11 Clinical trial Fase IV). Investigadora Principal: A.R Oleñik Memmell

8. Clinical trial: "Prevención de parto pretérmino en mujeres de riesgo identificadas por ecografía: evaluación de dos estrategias terapéuticas" (NºEUDRACT 2012-000241-13 Clinical trial Fase IV). Investigadora Principal: E. Carbajo Pérez.

9. Clinical trial " Ensayo multicéntrico, aleatorizado, comparativo y Add-on, en dos grupos paralelos para evaluar la eficacia y seguridad de las células troncales mesenquimales autólogas derivadas de tejido adiposo expandidas (ASC), para el tratamiento de la patología fistulosa perianal compleja en pacientes sin enfermedad inflamatoria intestinal" (NºEUDRACT: 2012-001178-28 Multicéntrico). Investigador Principal: D. García Olmo.

10. Clinical trial "Ensayo en Fase IIa para conocer la factibilidad y seguridad del uso de la fracción vasculo estromal del tejido adiposo para el tratamiento local de fístulas enterocutáneas asociadas a la enfermedad de Crohn". (NºEUDRACT: 2010-024308-82).
Investigador Principal: M. García Arranz

11. Clinical trial "Ensayo en fase I-II para conocer la factibilidad y seguridad del uso de la fracción vasculo estromal del tejido adiposo para el tratamiento local de fístulas recto-vaginales de Crohn" (NºEUDRACT: 2010-024330-35). Investigadora Principal: Mª Dolores Herreros Marcos.

12. Clinical trial en Fase IIa para el tratamiento de la fistula perianal extremadamente compleja y resistente al tratamiento convencional, con células madre autólogas obtenidas de lipoaspirado" (NºEUDRACT: 2010-024329-19. Clinical trial Fase IIIa). Investigador Principal: D. García Olmo.

13. Clinical trial "Estudio Fase III, multicéntrico, aleatorizado, doble ciego, de grupos paralelos y controlado con placebo para evaluar la eficacia y la seguridad de células madre alogénicas expandidas derivadas del tejido adiposo (eASC) para el tratamiento de la enfermedad de Crohn fistulizante perianal tras un periodo de 24 semanas y un periodo de seguimiento extendido hasta las 52 semanas. Estudio ADMIRE-CD". (NºEUDRACT: 2011-006064-43. Clinical trial Fase III. Multicéntrico). Investigador principal: C. Pastor Idoate.

14. Observational studies "Implantes cocleares en hipoacusias asimétricas CEL5312" Ref. 4021/003.
Investigador Principal: C.J. Cenjor Español.

15. Observational studies "Estudio epidemiológico, prospectivo, para evaluar el valor diagnóstico del inmunofenotipo por citometría de flujo en la carcinomatosis de células epiteliales" Ref. 14257/001.
Investigadora Principal: R. García Castellano.

16. Observational studies "Observational studies postautorización, prospectivo para desarrollar y validar una herramienta pronóstica que permita optimizar las terapias en pacientes con hepatitis crónica C genotipo 1 y 4" Ref. 4567/002.
Investigadora Principal: A. González Guirado.

17. Observational studies "Observational studies retrospectivo para evaluar la eficacia y seguridad a largo plazo de la monoterapia con ENTECAVIR en la práctica clínica habitual en pacientes con hepatitis crónica B navie al tratamiento con análogos de nucleótidos. Estudio ORI" Ref. 4567/003.
Investigadora Principal: A. González Guirado.

18. Observational studies "Observational studies postautorización de seguridad (EPAs) con VICTRELISTM, (BOCEPREVIR) en pacientes con hepatitis C crónica" Ref. 4567/004.
Investigadora Principal: A. González Guirado.

19. Observational studies "Estudio EMERG-AF (EMERGENCY DEPARTMENT STROKE PROPHULAXIS AND GUIDELINES IMPLEMENTATION IN ATRIAL FIBRILLATION): implementación de las guías de fibrilación auricular y profilaxis de ictus de los servicios de urgencia" Ref. EO 69/2012.
Investigadora Principal: B. Rodríguez Miranda