Pulmonology

Heads

• Nicolás González Mangado (Head of Service, Head of Group CIBERES / Assistant Professor, UAM)
• Germán Peces Barba Romero (Assistant Professor, UAM)
• Luis Seijo Maceiras

Research staff

• Javier Flandes Aldeyturriaga
• Teresa Gómez García
• Sarah Beatriz Heili Frades
• Rosario Melchor Íñiguez
• Mª Jesús Rodríguez Nieto
• Mª Fernanda Troncoso Acevedo
• Felipe Villar Álvarez
• Sandra Pérez Rial

Trainee staff

• Sara Robles Mateo

Technical staff and assistants

• José Fernández Arias

Staff research associates

• Teresa Presa (Radiology)
• Sara Antúnez (Thoraric surgery)
• Francisco Roig (Pulmonology, Hospital Infanta Elena)

Main lines of research

Sleep apnea

There is growing evidence indicating that sleep apnea hypopnea syndrome (SAHS) may be a risk factor for cardiovascular morbidity and mortality. Systemic mechanisms, such as intermittent hypoxia and oxidative stress, play an important intermediary role in these cardiovascular outcomes and may be candidate biological markers of the disease. Some of these pathophysiologic pathways also appear to be strongly involved in the pathogenesis of other diseases, such as cancer.

While SAHS is a very common disease in both men and women, certain population groups (e.g. women) can present with a form of airway obstruction with different symptoms but similar cardiovascular consequences; this condition has not been fully studied, and evidence of the effectiveness of CPAP treatment is lacking.

The lines of research are related to these areas, and include participation in a project focusing on the metabolomic analysis of blood samples, international projects studying the relationship between heart failure and sleep apnea, and national projects investigating the link between SAHS and melanoma in women.

* Principal Investigator: Nicolás González Mangado

Lung cancer

Lung cancer causes more deaths than any other type of malignant tumor, mainly because the vast majority (over 80%) of patients with this disease are diagnosed in advanced stages. In the past 15 years several international clinical trials have shown that computed tomography (CT) scanning using low doses of radiation can detect lung cancer in its early stages. These cancers are curable in a very high percentage of individuals (about 90%). It has been demonstrated that annual screening using this imaging technique can reduce mortality due to lung cancer by at least 20%.

Fundación Jiménez Díaz has implemented an early detection screening program, the main objective of which is to diagnose lung cancer in high-risk patients, especially those with impaired lung function or emphysema.

The lines of research associated with this initiative are part of the CIBER respiratory diseases program, and form part of its strategic plan for lung cancer. The aims are to study 1) the risk of each individual based on exposure to tobacco smoke and personal and family history; 2) the influence of associated diseases, especially chronic obstructive pulmonary disease (COPD) and emphysema, on the risk of developing lung cancer and its prognosis; and 3) genetic and molecular factors that determine the risk profile of each individual.

* Principal Investigator: Luis Seijo Maceiras

COPD

The COPD line of research is oriented towards the study of the pathogenesis of this disease using animal models, and includes the study of susceptibility to developing lung damage and its progression to established COPD. Goals include the identification of key biomarkers of the development or progression of the disease and their translation to clinical settings. This research has been undertaken in 2 cohorts of patients, one with recent COPD onset and another with severe, late-stage COPD. Our group also experiments with new therapeutic targets based on the use of growth factors in experimental models of the disease and endoscopic implantation of coils and valves for the treatment of emphysema.

* Principal Investigator: Germán Peces-Barba

Publications (2014)

1. Gex Gregoire Pralong Jacques A Combescure Christophe Seijo Luis Rochat Thierry Soccal Paola M .Diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules: a systematic review and meta-analysis.Respiration. 2014;87(2):165-76. doi: 10.1159/000355710. Epub 2014 Jan 3. Review..PudMed PMID:24401166

2. Casanova C, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, Peces-Barba G, Calle-Rubio M, Solanes-García I, Agüero R, de Diego-Damia A, Feu-Collado N, Alfageme I, Irigaray R, Balcells E, Llunell A, Galdiz JB, Marín M, Soler-Cataluña JJ, Lopez-Campos JL, Soriano JB, de-Torres JP, COPD History Assessment In SpaiN (CHAIN) cohort.New GOLD classification: longitudinal data on group assignment.Respir Res. 2014 Jan 13;15:3. doi: 10.1186/1465-9921-15-3. Erratum in: Respir Res. 2014;15:140. .PudMed PMID:24417879

3. Salcedo PS, Seijo LM, Zulueta JJ.Endobronchial valves for advanced emphysema: an endobronchial follow-up.J Bronchology Interv Pulmonol. 2014 Jan;21(1):47-50. doi: 10.1097/LBR.0000000000000035..PudMed PMID:24419186

4. Gómez García MT, Troncoso Acevedo MF, Rodriguez Guzmán M, Alegre de Montaner R, Fernández Fernández B, Del Río Camacho G, González-Mangado N.Can pulse transit time be useful for detecting hypertension in patients in a sleep unit?Arch Bronconeumol. 2014 Jul;50(7):278-84. doi: 10.1016/j.arbres.2013.12.001. Epub 2014 Jan 24. English, Spanish. .PudMed PMID:24468130

5. de Torres Juan P Marin Jose M Martinez-Gonzalez Cristina de Lucas-Ramos Pilar Mir-Viladrich Isabel Cosio Borja Peces-Barba German Calle-Rubio Miryam Solanes-García Ingrid Agüero Balbin Ramón de Diego-Damia Alfredo Feu-Collado Nuria Alfageme Michavila Inmaculada Irigaray Rosa Balcells Eva Llunell Casanovas Antònia Galdiz Iturri Juan Bautista Marín Royo Margarita Soler-Cataluña Juan J Lopez-Campos Jose Luis Soriano Joan B, Casanova Ciro, .Clinical application of the COPD assessment test: longitudinal data from the COPD History Assessment in Spain (CHAIN) cohort.Chest. 2014 Jul;146(1):111-22. doi: 10.1378/chest.13-2246..PudMed PMID:24522636

6. Rodriguez-Guzman M, Gallegos-Carrera B, Vicente-Antunes S, Fernandez-Ormaechea I, Zapatero-Gaviria J, Villar-Alvarez F.Spontaneous Hemothorax in a Patient With von Recklinghausen's Disease.J Clin Med Res. 2014 Apr;6(2):149-52. doi: 10.14740/jocmr1692w. Epub 2014 Feb 6..PudMed PMID:24578758

7. Sánchez de Cos Escuín J, Abal Arca J, Melchor Íñiguez R, Miravet Sorribes L, Núñez Ares A, Hernández Hernández JR, García Arangüena L, Núñez Delgado M, Pavón Fernández MJ, Francisco Corral G, de Esteban Júlvez L, González Budiño MT, Abad Cavaco F, Ansótegui Barrera E, Andreo García F, Serra Mitjans M, Hernández Rodríguez H.Tumor, node and metastasis classification of lung cancer--M1a versus M1b--analysis of M descriptors and other prognostic factors.Lung Cancer. 2014 May;84(2):182-9. doi: 10.1016/j.lungcan.2014.02.006. Epub 2014 Feb 23..PudMed PMID:24629637

8. Barros Casas D, Fernadez S, Folch E, Flandes Aldeyturriaga J, Majid A.Non-malignant central airway obstruction.Arch Bronconeumol. 2014 Aug;50(8):345-54. doi: 10.1016/j.arbres.2013.12.012. Epub 2014 Apr 3. English, Spanish. .PudMed PMID:24703501

9. Esquinas AM, Zamarro García C, Rey Terrón L..Trends of hospital admissions for acute exacerbation of COPD in Spain: are we needing a new of hospital and health system organization reappraisal?Respir Med. 2014 Jul;108(7):1066-7. doi: 10.1016/j.rmed.2014.01.015. Epub 2014 Apr 28. .PudMed PMID:24820244

10. Del-Río Camacho G, Martínez González M, Sanabria Brossart J, Gutiérrez Moreno E, Gómez García T, Troncoso Acevedo F.Post-operative complications following adenotonsillectomy in children with severe sleep apnea-hypopnea syndrome. Do they need to be admitted to an intensive care unit?Acta Otorrinolaringol Esp. 2014 Sep-Oct;65(5):302-7. doi: 10.1016/j.otorri.2014.03.004. Epub 2014 Jun 2. English, Spanish. .PudMed PMID:24882467

11. Abad MS, Trueba IM, Almaraz CS, Ezquibela AC, Vázquez FJ.Pulmonary hydatidosis.Chin Med J (Engl). 2014;127(13):2551. .PudMed PMID:24985601

12. González Mangado N, Troncoso Acevedo MF, Gómez García T.Home ventilation therapy in obstructive sleep apnea-hypopnea syndrome.Arch Bronconeumol. 2014 Dec;50(12):528-34. doi: 10.1016/j.arbres.2014.06.003. Epub 2014 Jul 22. English, Spanish. .PudMed PMID:25059585

13. Pérez-Rial Sandra Girón-Martínez Alvaro Peces-Barba Germán .Animal models of chronic obstructive pulmonary disease.Arch Bronconeumol. 2015 Mar;51(3):121-7. doi: 10.1016/j.arbres.2014.06.016. Epub 2014 Sep 5. English, Spanish. .PudMed PMID:25201221

14. Masa Juan F Duran-Cantolla Joaquin Capote Francisco Cabello Marta Abad Jorge Garcia-Rio Francisco Ferrer Antoni Mayos Merche Gonzalez-Mangado Nicolas de la Peña Monica Aizpuru Felipe Barbe Ferran Montserrat Jose M .Effectiveness of home single-channel nasal pressure for sleep apnea diagnosis.Sleep. 2014 Dec 1;37(12):1953-61. doi: 10.5665/sleep.4248..PudMed PMID:25325484

15. Masa Juan F Duran-Cantolla Joaquin Capote Francisco Cabello Marta Abad Jorge Garcia-Rio Francisco Ferrer Antoni Fortuna Ana M Gonzalez-Mangado Nicolas de la Peña Monica Aizpuru Felipe Barbe Ferran Montserrat Jose M .Efficacy of home single-channel nasal pressure for recommending continuous positive airway pressure treatment in sleep apnea.Sleep. 2015 Jan 1;38(1):13-21. doi: 10.5665/sleep.4316..PudMed PMID:25325508

16. Girón-Martínez Alvaro Pérez-Rial Sandra Terrón-Expósito Raúl Díaz-Gil Juan José González-Mangado Nicolás Peces-Barba Germán .Proliferative activity of liver growth factor is associated with an improvement of cigarette smoke-induced emphysema in mice.PLoS One. 2014;9(11):e112995. doi: 10.1371/journal.pone.0112995..PudMed PMID:25401951

17. B. Morales Chacón, I. Alí García, N. Abad Santamaría, E. De Santiago Delgado, M. Izquierdo Patrón5, Y. Martínez Abad, R. Pérez Rojo, M.T. Río Ramírez, B. Steen, R. Melchor Iñiguez Grupo de Trabajo de Pleura de Neumomadrid.Características generales del derrame pleural maligno secundario a neoplasias de diferentes orígenesRevista de Patología Respiratoria2014.PudMed PMID:0

18. L. Seijo.Lung Cancer Screening with Low Dose Computed TomographyMagazine of European Medical Oncology 2014.PudMed PMID:0

Projects (2013)

1. "Grupo de investigación CIBER de Enfermedades Respiratorias". Investigador Principal: N. González Mangado. Proyecto Público Competitivo CIBERES.

2. PI13/01909 "Identificación de marcadores de actividad desde el inicio de la EPOC en modelos experimentales y evaluación terapéutica con el factor de crecimiento LGF". Investigador Principal: G. Peces-Barba. Acción Estratégica en Salud 2013-2016.

3. NANOCOPD "Bioorthogonal nanoparticles for COPD theranostics". Investigador Principal: G. Peces-Barba. Proyectos colaborativos multidisciplinares CIBERBBN-SEPAR-CIBERES en patologías respiratorias.

4. SEPAR#139 "Role of the liver growth factor (LGF) like regenerative experimental lung emphysema". Investigador Principal: S. Pérez-Rial. Ayudas a la Investigación SEPAR (Sociedad Española de Neumología y Cirugía Torácica).

5. NMD2012 "Identificación de nuevos mecanismos patogénicos, desencadenados mediante la activación de la arginasa en pacientes con EPOC en fase estable, exacerbada y en asociación con bronquiectasias". Investigador Principal: F. Villar-Álvarez. Sociedad Madrileña de Neumología (NEUMOMADRID).

Clinical trials and Observational studies (2013)

1. Clinical trial "Estudio del AERISEAL SYSTEM para la reducción de la hiperinflación en el enfisema (ASPIRE)". (NºEUDRACT: NA. Clinical trial Fase NA). Investigador Principal: J. Flandes Aldeyturriaga.

2. Clinical trial "Estudio multicéntrico aleatorio para evaluar los efectos de ventilación servo-adaptativa (ASV) sobre la supervivencia y frecuencia de ingresos hospitalarios cardiovasculares (CV) en pacientes con fallo cardíaco (CV) y apnea del sueño (SA)- ADVENT-HF" (NºEUDRACT: NA. Clinical trial Fase NA, Multicéntrico Internacional). Investigador Principal: N. González Mangado.

3. Clinical trial "Estudio clínico aleatorizado, doble ciego, controlado con placebo, para evaluar el efecto sobre la función endotelial de ROFLUMILAST en pacientes con enfermedad pulmonar obstructiva crónica"-REVASC (NºEUDRACT: 2011-005047-27. Clinical trial Fase IV, Multicéntrico). Investigador Principal: G. Peces Barba Romero.

4. Clinical trial "Estudio aleatorizado, doble ciego, con doble simulación y grupos paralelos, comparativo de Fluticasona propionato/formoterol fumarato (FLUTIFORM) 250/10 UG (2 inhalaciones dos veces al día) frente a Formoterol fumarato dihidrato (ATIMOS) 12 UG (1 inhalación dos veces al día) en sujetos con enfermedad pulmonar obstructiva crónica (EPOC)". (NºEUDRACT: 2012-004162-17. Clinical trial Fase III, Multicéntrico Internacional). Investigador Principal: F.J. Roig Vázquez.

5. Observational studies "Caracterización de los pacientes con enfermedad pulmonar obstructiva crónica a lo largo de 24 horas (Estudio Assess)". TRIAL FORM SUPPORT, S.L. Ref. 11643/002. Investigador Principal: J. Gómez Seco.

6. Observational studies "Caracterización fenotípica de la población EPOC en España: clasificación de fenotipos clínicos de la EPOC y evaluación del diagnóstico y tratamiento en práctica habitual (Estudio FENEPOC)". TRIAL FORM SUPPORT, S.L. Ref. 4769/001. Investigador Principal: G. Peces-Barba Romero.

7. Observational studies "Estudio Sobre la Evolución Multidimensional de la Enfermedad Pulmonar Obstructiva Crónica (Estudio CHAIN)". Investigador Principal: G. Peces-Barba Romero.