Mitochondrial Calcium signaling

Heads

• Jorgina Satrústegui Gil-Delgado (Professor, UAM)

Research staff

• Laura Contreras Balsa
• Araceli del Arco Martínez
• Beatriz Pardo Merino
• Javier Traba Domínguez

Trainee staff

• Paloma González-Sánchez
• Irene Llorente polch
• Paula Martínez Valero
• Carlos Bienvenido Rueda Díez

Technical staff and assistants

• Isabel Mando Gavilán
• Bárbara Beatriz Sesé Cobos

Main lines of research

Global Cerebral Hypomyelination

Study of the pathological mechanisms of the disease caused by mutations in Aralar/AGC1 using AGC1-deficient mice. Effects on myelination, formation of brain N-acetyl aspartate, glial synthesis of glial glutamate and glutamine. Involvement of Aralar/AGC1 in other diseases in which decreases in brain NAA are implicated.

Charcot–Marie–Tooth disease

Changes in calcium signaling mechanisms, in particular mitochondrial signaling, in CMT caused by mutations in GDAP and MFN2.

Mitochondrial pathology

- Possible involvement of mutations in SCaMCs in mitochondrial diseases involving deletions in mitochondrial DNA and possible ophthalmoplegia.

- Possible involvement of SCaMC-3 mutations in diseases involving deletion or depletion of mitochondrial DNA in hepatic but not muscle tissue.

Regulation of calcium signaling to the mitochondria and calcium capture by the mitochondria

Role of calcium uniporter and mitochondrial transporters regulated by Aralar/AGC1 and SCaMCs. Role of these transporters in the dysregulation of mitochondrial calcium, mechanisms involved in human pathologies.

Mechanisms regulating tissue-specific oxidative phosphorylation

Mitochondrial retrograde signaling to the nucleus as a potential target in mitochondrial diseases

* Principal Investigator: Jorgina Satrústegui Gil-Delgado

Publications (2014)

1. Rueda CB, Llorente-Folch I, Amigo I, Contreras L, González-Sánchez P, Martínez-Valero P, Juaristi I, Pardo B, Del Arco A, Satrústegui J.Ca(2+) regulation of mitochondrial function in neurons.Biochim Biophys Acta. 2014 Oct;1837(10):1617-24. doi: 10.1016/j.bbabio.2014.04.010. Epub 2014 May 10..PubMed PMID:24820519

2. Lindsay Ken J Du Jianhai Sloat Stephanie R Contreras Laura Linton Jonathan D Turner Sally J Sadilek Martin Satrústegui Jorgina Hurley James B .Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15579-84. doi: 10.1073/pnas.1412441111. Epub 2014 Oct 13..PubMed PMID:25313047