Innovation in Ophthalmology
2023 DATA
Persons in charge
LRs
Research
|
LocationOphthalmology Service. Hospital Universitario Fundación Jiménez Díaz. Avda. Reyes Católicos, 2. 28040 Madrid (España). Key wordsArtificial intelligence, big data, intraocular implants, accommodation and presbyopia, corneal ectasias, corneal biomechanics, hereditary retinal and choroidal diseases, ocular genetics, ocular electrophysiology, gene therapy, stem cells, uveitis, ocular inflammation, clinical trials. |
Gender perspective
Activity summary
The group participates in several basic and clinical research projects mainly focused on the application of big data and artificial intelligence in biomedical image processing, in collaboration with other departments of the Autonomous University of Madrid and other universities, as well as the Daza Valdés Optics Institute, belonging to the Higher Council for Scientific Research (CSIC). The group is part of national research network programmes (RICORS-REI and RICORS-TERAV). It also participates in clinical trials funded by industry and independent clinical research (ISCIII competitive calls), focused on finding new therapies for ocular surface pathologies, uveitis and retinal diseases, especially hereditary ones.
Contributions to society
The group has actively collaborated with various patient societies such as AUEVEA, Retimur, ONCE, and Retina Madrid, both by participating in patient training sessions and by collaborating in the creation of informative material.
Collaborations
The group formally collaborates with the Daza Valdés Optics Institute of the CSIC and the Autonomous University of Madrid.
PhD Theses
List of publications ordered by publication date
Ametropia detection using a novel, compact wavefront autorefractor.
Hernández CS, Gil A, Zaytouny A, Casares I, Poderoso J, de Lara A, Wehse A, Dave SR, Lim D, Lage E, Alejandre-Alba N.
Ophthalmic Physiol Opt. 2023 Dec 12.
PMID: 38084770
FI: 2,9
Knowledge and Current Practices in Monogenic Uveitis: An International Survey by IUSG and AIDA Network.
Gaggiano C, Gupta V, Agrawal R, De Smet MD, Frediani B, Tosi GM, Paroli MP, Sridharan S, Pavesio CE, Pleyer U, Denisova EV, Babu K, de-la-Torre A, Yang P, Davis JL, Cunningham ET, Carreño E, Goldstein D, Fonollosa A, Cantarini L, Sobrin L, Fabiani C.
Ophthalmol Ther. 2023 Nov 04.
PMID: 37924480
FI: 3,3
Intravitreal fluocinolone acetonide 0.19 mg (ILUVIEN®) in patients with non-infectious uveitis: real-world effectiveness and safety outcomes at 12 months.
Moll-Udina A, Hernanz I, Sainz-de-la-Maza M, Pelegrín L, Coelho-Borges AI, Pazos M, Adán A, Llorenç V.
Int Ophthalmol. 2023 Nov.43(11):4181-4195.
PMID: 37698661
FI: 1,6
KCNV2-associated retinopathy: genotype-phenotype correlations - KCNV2 study group report 3.
de Guimaraes TAC, Georgiou M, Robson AG, Fujinami K, Vincent A, Nasser F, Khateb S, Mahroo OA, Pontikos N, Vargas ME, Thiadens AAHJ, Carvalho ER, Nguyen XT, Arno G, Fujinami-Yokokawa Y, Liu X, Tsunoda K, Hayashi T, Jiménez-Rolando B, Martin-Merida MI, Avila-Fernandez A, Salas EC, Garcia-Sandoval B, Ayuso C, Sharon D, Kohl S, Huckfeldt RM, Banin E, Pennesi ME, Khan AO, Wissinger B, Webster AR, Heon E, Boon CJF, Zrenner E, Michaelides M.
Br J Ophthalmol. 2023 Oct 18.
PMID: 37852740
FI: 4,1
Description of Macrophage-Like Cells in Active Ocular Toxoplasmosis.
Carreño E, Hernanz I, Collado B, Pichi F.
Ocul Immunol Inflamm. 2023 Oct 03:1-4.
PMID: 37787936
FI: 3,3
Ocular involvement in adult and paediatric patients with monogenic autoinflammatory diseases: a Spanish multicentre retrospective study.
Fonollosa A, Pelegrín L, García-Morillo S, Buján-Rivas S, Distefano L, Robles-Maruenda A, Fernández-Martín J, González-García A, Garcia-Aparicio Á, Ortego-Centeno N, Llorenç V, Sainz de la Maza M, Pinedo C, Sopeña B, Cocho L, Carreño E, Blanco R, Antón J, Pérez-Quintana M, Marques-Soares JR, Artaraz J, Ruiz-Arruza I, Soto-Peleteiro A, Gómez-Caverzaschi V, Araújo O, Espinosa G, Adan A, Fabiani C, Cantarini L, Hernández-Rodríguez J, Spanish Society of Ocular Inflammation (SEIOC) and the AutoInflammatory Diseases Alliance (AIDA) Network.
Clin Exp Rheumatol. 2023 Sep 28.
PMID: 37812477
FI: 3,7
Herpetic anterior uveitis following COVID-19 vaccines: a case series.
Ott M, Nagamany T, Zandi S, Pichi F, Agarwal A, Carreño E, Gupta V, Grewal DS, Cunningham ET, Munk MR.
Front Med (Lausanne). 2023.10:1242225.
PMID: 37809344
FI: 3,9
The humira in ocular inflammations taper (HOT) study.
Pichi F, Smith SD, Goldstein DA, Baddar D, Gerges TKA, Janetos TM, Ruiz-Cruz M, Concha-Del-Río LE, Maruyama K, Carina Ten Berge J, Rombach SM, Cimino L, Bolletta E, Miserocchi E, Scandale P, Serafino M, Camicione P, Androudi S, Gonzalez-Lopez JJ, Lim LL, Singh N, Gupta V, Gupta N, Amer R, Md EMD, Md SI, Munk MR, Donicova E, Carreño E, Takeuchi M, Chee SP, Chew MC, Agarwal A, Schlaen A, Gómez RA, Couto CA, Khairallah M, Neri P.
Am J Ophthalmol. 2023 Sep 19.
PMID: 37734639
FI: 4,2
In Vivo Visualization of Macrophage-Like Cells in Patients with Uveitis by Use of En Face Swept Source Optical Coherence Tomography.
Pichi F, Neri P, Aljeneibi S, Hay S, Chaudhry H, Saturno MC, Carreno E.
Ocul Immunol Inflamm. 2023 Sep 18:1-7.
PMID: 37722841
FI: 3,3
Diagnostic and Management Strategies of Tubulointerstitial Nephritis and Uveitis Syndrome (TINU): Current Perspectives.
Sanchez-Quiros J, Giralt L, Fonollosa A, Robles I, Carreño E.
Clin Ophthalmol. 2023.17:2625-2630.
PMID: 37701464
FI: 2,2
Multimodal Imaging Study of Patients With Vitamin A Deficiency Retinopathy.
Pichi F, Aljneibi S, Neri P, Rishi P, Cicinelli MV, Introini U, Sharma S, Munk MR, Pasadhika S, Gonzalez-Lopez JJ, Lembo A, Nucci P, Choudhry N, Carreño E.
Ophthalmic Surg Lasers Imaging Retina. 2023 Jun.54(6):330-336.
PMID: 37352397
FI: 1
Hypopyon Uveitis as a Manifestation of Primary Choroidal Lymphoma.
Vidal C, Robles I, Escamilla N, Losada D, Serrano C, Miranda C, Pastor AI, Carreño E.
Ocul Immunol Inflamm. 2023 Jun 21:1-3.
PMID: 37343273
FI: 3,3
Systemic Vasculitis and Its Association with the Eye.
Carreño E, Olivas-Vergara OM.
Ophthalmologica. 2023.246(3-4):174-180.
PMID: 37331330
FI: 2,6
Comprehensive genotyping and phenotyping analysis of GUCY2D-associated rod- and cone-dominated dystrophies.
Rodilla C, Martín-Merida I, Blanco-Kelly F, Trujillo-Tiebas MJ, Avila-Fernandez A, Riveiro-Alvarez R, Pozo-Valero MD, Perea-Romero I, Swafiri ST, Zurita O, Villaverde C, López MA, Romero R, Iancu IF, Núñez-Moreno G, Jiménez-Rolando B, Martin-Gutierrez MP, Carreño E, Minguez P, García-Sandoval B, Ayuso C, Corton M.
Am J Ophthalmol. 2023 Jun 15.
PMID: 37327959
FI: 4,2
Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study.
Velarde-Rodriguez G, Belda-Para C, Velasco-Ocaña M, Trujillo-Sevilla JM, Rodríguez-Martin J, Jiménez-Alfaro I, Rodriguez-Ramos JM, Alejandre-Alba N.
Ophthalmol Ther. 2023 Jun.12(3):1569-1582.
PMID: 36856979
FI: 3,3
The retinal bacillary layer detachment: Clinical features and outcomes in posterior uveitis.
Hernanz I, Moll-Udina A, Garcia-Tirado A, Garcia-Fernandez M, Gutierrez-Ezquerro R, Garcia-Arumi C, Llorenç V, Cuadros C, Fonollosa A, Sainz-de-la-Maza M, Adán A.
J Fr Ophtalmol. 2023 May 18.
PMID: 37210295
FI: 1,2
IMPULSE Study: Impact of COVID-19 in the present of ophthalmology focusing on ocular surface and future trends.
Benítez Del Castillo JM, Alejandre Alba N, Henares I, Ferraris MP, Águila M.
Arch Soc Esp Oftalmol (Engl Ed). 2023 Apr.98(4):213-219.
PMID: 36878286
FI: 0
Retinal vein occlusion. Audit of a specialized care program.
Rueda-Camino JA, Gimena-Rodríguez FJ, Domínguez-Sepúlveda MA, Bolzoni M, Pastor-Vivas AI, Angelina-García M, Joya-Seijo MD, Trujillo-Luque D, Losada-Bayo D, Barba-Martín R.
Rev Clin Esp (Barc). 2023 Feb.223(2):84-89.
PMID: 36646420
FI: 2,9
Tubulointerstitial Nephritis and Uveitis Syndrome (TINU) after Intake of Dietary Supplement.
Vidal C, Robles I, Carreño E.
Ocul Immunol Inflamm. 2023 Jan 10:1-2.
PMID: 36628464
FI: 3,3
Projects, contracts and observational studies
PUBLIC
Sources of public funding for projects being developed at the IIS-FJD:
|
REFERENCE |
PROJECT TITLE |
PRINCIPAL RESEARCHER |
TYPE OF PROJECT |
TOTAL FUNDING |
|
ICI21/00060 |
ENSAYO CLÍNICO EN FASE IIA PARA CONOCER LA FACTIBILIDAD Y SEGURIDAD DEL USO DE ASC ALOGÉNICAS EN EL TRATAMIENTO DE LAS CONJUNTIVITIS CICATRICIALES ACTIVAS ASOCIADAS A SÍNDROME DE LYELL, STEVEN JOHNSON Y PERFIGOIDE |
ALEJANDRE ALBA NICOLAS |
PROYECTO DE INVESTIGACIÓN CLÍNICA INDEPENDIENTE |
276.166,00 € |
|
ICI19/00020-EXT |
EFFICACY, SAFETY AND COST-EFFECTIVENESS OF METHOTREXATE, ADALIMUMAB, OR THEIR COMBINATION IN NON INFECTIOUS NON ANTERIOR UVEITIS: A MULTICENTER, RANDOMIZED, PARALLEL 3 ARM, ACTIVE-CONTROLLED, PHASE 3 OPEN LABEL WITH BLINDED OUTCOME ASSESSMENT STUDY. |
CARREÑO SALAS ESTER |
PROYECTO DE INVESTIGACIÓN CLÍNICA INDEPENDIENTE |
17.823,44 € |
PRIVATE
|
REFERENCE |
PROJECT TITLE |
PRINCIPAL RESEARCHER |
TYPE OF PROJECT |
|
10964/003 |
APOYO A LOS PROYECTOS DE INVESTIGACIÓN EN MIELOMA MÚLTIPLE REALIZADOS EN EL SERVICIO DE OFTALMOLOGÍA DEL HOSPITAL UNIVERSITARIO FUNDACIÓN JIMÉNEZ DÍAZ, MEDIANTE LA CONTRATACIÓN DE UN DATA MANAGER |
ALEJANDRE ALBA NICOLAS |
PROYECTOS PRIVADOS NO COMPETITIVOS |
|
PIC164-21_FJD |
PROYECTO DE INVESTIGACION PROSPECTIVO PARA EVALUAR EL EDEMA CORNEAL EN EL POSTOPERATORIO INMEDIATO TRAS CIRUGIA DE CATARATAS TRATADO CON SOLUCION HIPERTONICA |
ALEJANDRE ALBA NICOLAS |
PROYECTOS PRIVADOS NO COMPETITIVOS |
|
PIC188-21_FJD |
EVALUACION DE UN AUTOREFRACTOMETRO DE FRENTE DE ONDA PORTATIL PARA MEDIR ERRORES DE REFRACCION Y ABERRACIONES DEL OJO HUMANO |
ALEJANDRE ALBA NICOLAS |
PROYECTOS PRIVADOS NO COMPETITIVOS |
|
PIC204-23_FJD |
CLINICAL IMPACT OF THE INTRAOCULAR LENS TILT AND DECENTRATION ON VISUAL PERFORMANCE |
ALEJANDRE ALBA NICOLAS |
PROYECTOS PRIVADOS NO COMPETITIVOS |
|
41065/001 |
LUMINA: ESTUDIO DE FASE III MULTICENTRICO, ALEATORIZADO, DOBLE CIEGO, CONTROLADO POR SIMULACION PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE INYECCIONES INTRAVÍTREAS DE 440 UG DE DE-109 EN EL TRATAMIENTO DE LA UVEITIS ACTIVA NO INFECCIOSA DEL SEGMENTO POSTERIOR DEL OJO |
CARREÑO SALAS ESTER |
PROYECTOS PRIVADOS NO COMPETITIVOS |
|
PIC075-21_FJD |
ESTUDIO PARA DETERMINAR LA PRESENCIA DE PACIENTES CON XLRP CONFIRMADA GENETICAMENTE Y ASOCIADA CON EL GEN RPGR EN CENTROS DE INVESTIGACION PARA SU POSIBLE PARTICIPACION EN FUTUROS ESTUDIOS DE INVESTIGACION CLINICA |
GARCIA SANDOVAL BLANCA |
PROYECTOS PRIVADOS NO COMPETITIVOS |
|
4269/003 |
SERVICIO OFTALMOLOGÍA |
JIMENEZ ALFARO MOROTE IGNACIO |
OTRAS ACTIVIDADES DE INVESTIGACION |
|
24319/001 |
SERVICIO OFTALMOLOGIA HRJC |
SANTANDER GARCIA DIANA |
OTRAS ACTIVIDADES DE INVESTIGACION |
Clinical trials
The clinical trials listed below were in the recruitment phase in 2023. If you are interested in participating in any of the currently open trials, more information is available on the website (https://ensayos.quironsalud.es/)
|
EudraCT Number |
TITLE |
PHASE |
MC1 |
INT2 |
PRINCIPAL RESEARCHER |
|
2021-005486-40 |
ENSAYO CLINICO EN FASE IIA MULTICENTRICO PARA CONOCER LA FACTIBILIDAD Y SEGURIDAD DEL USO DE CELULAS TRONCALES MESENQUIMALES DERIVADAS DEL TEJIDO ADIPOSO (ASC) EN EL TRATAMIENTO DE PACIENTES CON CONJUNTIVITIS CICATRICIALES ASOCIADAS A SINDROME DE LYELL, SINDROME STEVENS- JOHNSON Y PENFIGOIDE DE LAS MEMBRANAS MUCOSAS CON AFECTACION OCULAR |
II |
SI |
SI |
ALEJANDRE ALBA NICOLAS |
|
2021-006498-49 |
ESTUDIO DE FASE IIB PIVOTAL PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE IZOKIBEP EN SUJETOS CON UVEITIS INTERMEDIA, POSTERIOR, NO INFECCIOSA O PANUVEITIS - (21103) |
II |
SI |
SI |
CARREÑO SALAS ESTER |
|
2022-500746-16-00 |
A PHASE 2B, RANDOMIZED, DOUBLE-MASKED, MULTICENTER, DOSE-RANGING, SHAM-CONTROLLED CLINICAL TRIAL TO EVALUATE INTRAVITREAL JNJ-81201887 (AAVCAGSCD59) COMPARED TO SHAM PROCEDURE FOR THE TREATMENT OF GEOGRAPHIC ATROPHY (GA) SECONDARY TO AGE-RELATED MACULAR DEGENERATION (AMD) |
II |
SI |
SI |
MUÑOZ SANZ NÉLIDA |
|
2022-002158-15 |
TIVANISIRAN PARA EL OJO SECO EN SUJETOS CON SINDROME DE SJÖGREN |
III |
SI |
SI |
ALEJANDRE ALBA NICOLAS |
|
2020-000130-18 |
EFICACIA, SEGURIDAD Y COSTE-EFECTIVIDAD DEL METOTREXATO, ADALIMUMAB, O SU COMBINACION EN UVEITIS NO ANTERIOR NO INFECCIOSA: UN ESTDIO MULTICENTRICO, ALEATORIZADO PARALELO DE 3 BRAZOS, CON CONTROL ACTIVO, DE FASE 3, ABIERTO, CON EVALUADOR CEGADO: CO-THEIA (COMBINATIONTHERAPY WITH METHOTREXATE AND ADALLMUMAB FOR UVEITIS) |
III |
SI |
NO |
CARREÑO SALAS ESTER |
|
2022-001622-29 |
ESTUDIO DE FASE IIIB ABIERTO, NO ALEATORIZADO, NO CONTROLADO Y MULTICENTRICO QUE EVALUA LA SEGURIDAD Y LA EFICACIA DEL IMPLANTE INTRAVITREO DE 190 MICROGRAMOS DE ACTONIDO DE FLUOCINOLONA EN SUJETOS PEDIATRICOS DE 6 AÑOS A MENOS DE 18 AÑOS CON UVEITIS NO INFECCIOSA RECURRENTE QUE AFECTA EL SEGMENTO POSTERIOR DEL OJO |
III |
SI |
SI |
CARREÑO SALAS ESTER |
|
2022-501794-39 |
A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-MASKED, SHAM-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF RO7200220 ADMINISTERED INTRAVITREALLY IN PATIENTS WITH UVEITIC MACULAR EDEMA |
III |
SI |
SI |
CARREÑO SALAS ESTER |
|
2020-002873-88 |
ESTUDIO DE FASE 3 ALEATORIZADO Y CONTROLADO DE AAV5-HRKP.RPGR PARA EL TRATAMIENTO DE LA RETINITIS PIGMENTOSA LIGADA AL CROMOSOMA X ASOCIADA CON VARIANTES EN EL GEN RPGR - (MGT-RPGR-021) |
III |
SI |
SI |
GARCIA SANDOVAL BLANCA |
|
2020-002873-88 |
ESTUDIO DE FASE 3 ALEATORIZADO Y CONTROLADO DE AAV5-HRKP.RPGR PARA EL TRATAMIENTO DE LA RETINITIS PIGMENTOSA LIGADA AL CROMOSOMA X ASOCIADA CON VARIANTES EN EL GEN RPGR - (MGT-RPGR-021) |
III |
SI |
SI |
GARCIA SANDOVAL BLANCA |
|
MC1: Multicéntrico INT2: Internacional |
|||||
Patents
Title: Dispositivo y procedimiento de obtención de medidas mecánicas, geométricas y dinámicas de superficies ópticas.
Application No: P201731354
Main entities: FIIS-FJD (50%), UPM (50%)
Inventors: Pablo Pérez Merino; Nicolás Alejandre Alba; Ignacio Jiménez-Alfaro Morote; Antonio Fernández López; Jesús Alfredo Güemes Gordo; Beatriz Larrañaga Valsero.
Title: Dispositivo y procedimiento de obtención de medidas mecánicas, geométricas y dinámicas de superficies ópticas.
Application No: U201930475
Main entities: FIIS-FJD (50%), UPM (50%)
Inventors: Pablo Pérez Merino; Nicolás Alejandre Alba; Ignacio Jiménez-Alfaro Morote; Antonio Fernández López; Jesús Alfredo Güemes Gordo; Beatriz Larrañaga Valsero.
Title: Device and method for obtaining mechanical, geometric, and dynamic measurements of optical surfaces.
Application No: PCT/ES2018/070757
Main entities: FIIS-FJD (50%), UPM (50%)
Inventors: Pablo Pérez Merino; Nicolás Alejandre Alba; Ignacio Jiménez-Alfaro Morote; Antonio Fernández López; Jesús Alfredo Güemes Gordo; Beatriz Larrañaga Valsero.
Title: Device and method for obtaining mechanical, geometric, and dynamic measurements of optical surfaces.
Application No: EP18849477.7
Main entities: FIIS-FJD (50%), UPM (50%)
Inventors: Pablo Pérez Merino; Nicolás Alejandre Alba; Ignacio Jiménez-Alfaro Morote; Antonio Fernández López; Jesús Alfredo Güemes Gordo; Beatriz Larrañaga Valsero.
Title: Method for determining a refractive correction for an optical system.
Application No: EP24382030.5
Main entities: FIIS-FJD (100%)
Inventors: Miguel Antonio Faria Ribeiro, Gonzalo Rafael Velarde Rodríguez, Nicolás Alejandre Alba, Ignacio Jiménez-Alfaro Morote.
