Regenerative Medicine and Tissue Bioengineering Associated Group

6.6.7. GRUPO ASOCIADO DE MEDICINA REGENERATIVA Y BIOINGENIERÍA DE TEJIDOS-220620-FOTO-web2023 DATA

Gender perspective

6.6.7-MED REGENERATIVA-GÉNERO

Activity summary

Our activities include:

• Clinical, pathophysiological, cellular and genetic characterisation of genodermatosis and other cutaneous pathologies.
• Use of 3D scaffold carrying Adult Stem Cells: Mesenchymal and/or Epithelial Stem Cells for skin regeneration.
• Use of epidermal stem cells corrected using genomic editing techniques for treating genodermatosis.
• Design of disease-modifying therapies in genodermatosis and its associated pathologies. Identification of biomarkers.

Contributions to society

In the last four years, numerous articles have been published and multiple competitive research projects have been carried out. Furthermore, over 1,100,000 euros have been raised through competitive calls for proposals, and over 800,000 euros through R&D contracts with the pharmaceutical industry, patient associations and private institutions. It is important to highlight the participation of group members as advisors in EB-Clinet, an international network of EB centers and advisors, and also on the Medical and Scientific Advisory Panel (MSAP) of the patient association DEBRA International. We have also obtained three patents and one orphan drug designation, and have participated in five clinical trials in the field of gene therapy and tissue bioengineering. We have published Clinical Practice Guidelines for Laboratory Diagnosis of Epidermolysis Bullosa. Lastly, we would like to highlight our participation as advisors at DEBRA-Spain and the Spanish Association of Patients with Ichthyosis.

Collaborations

Close collaboration with joint projects and publications:

• MEDICAL CENTER- UNIVERSITY OF FREIBURG University Hospital of Freiburg (Germany).
• Leitung Molekulare Dermatologie Leitung Genodermatosen-Sprechstunde UNIVERSITÄTSKLINIKUM FREIBURG. (Germany).
• St. John's Institute of Dermatology, King's College London (London, UK).
• IHU IMAGINE - Institut des maladies génétiques. Paris (France).
• Laboratorio di Biologia Molecolare e Cellulare Istituto Dermopatico dell'Immacolata - IRCCS. Rome (Italy).
• The Weizmann Institute of Science. Rehovot (Israel).

PhD Theses

6.6.7-MED REGENERATIVA-TESIS

List of publications ordered by publication date

Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs.

Martínez-Domínguez SJ, García-Mateo S, Sainz-Arnal P, Martínez-García J, Gallego-Llera B, Lozano-Limones MJ, Hidalgo S, Gargallo-Puyuelo CJ, Latre-Santos M, Nocito-Colon MML, Martínez-Lostao L, Refaie E, Arroyo-Villarino MT, Del Rio-Nechaevsky M, Ramirez-Labrada A, Pardo J, Gomollón F, Baptista PM.

Sci Rep. 2023 Dec 27.13(1):23061.

PMID: 38155275

FI: 4,6

Gluten-sensitive Enteropathy in Recessive Dystrophic Epidermolysis Bullosa.

Sacedón R, de Arriba MC, Martínez-Santamaría L, Maseda R, Herráiz-Gil S, Jiménez E, Rosales I, Quintana L, Illera N, García M, Butta N, Fernández-Bello I, Lwin SM, Fernández-Arquero M, León C, McGrath JA, Vicente MÁ, Del Río M, de Lucas R, Sánchez-Ramón S, Escámez MJ.

Br J Dermatol. 2023 Sep 01.

PMID: 37655918

FI: 10,3

Optical, non-invasive, Oxygen Concentration Estimation by Porphyrin Embedded in Skin Equivalents.

A. Matesanz, J. L. Jorcano, P. Bosch, D. Velasco, and P. Acedo.

Optica Sensing Congress 2023 (AIS, FTS, HISE, Sensors, ES). 2023, paper STu5C.7.

PMID: 10.1364/SENSORS.2023.STu5C.7

FI: 0

Multi-omic data integration in food science and analysis.

Sara Herráiz-Gil, María del Carmen de Arriba, María J Escámez, Carlos León.

Current Opinion in Food Science. 2023 52: 101049.

PMID: 10.1016/j.cofs.2023.101049

FI: 9,9

Technological advances in fibrin for tissue engineering.

Sanz-Horta R, Matesanz A, Gallardo A, Reinecke H, Jorcano JL, Acedo P, Velasco D, Elvira C.

J Tissue Eng. 2023.14:20417314231190288.

PMID: 37588339

FI: 8,2

In vitro induction of hair follicle signatures using human dermal papilla cells encapsulated in fibrin microgels.

Quílez C, Valencia L, González-Rico J, Suárez-Cabrera L, Amigo-Morán L, Jorcano JL, Velasco D.

Cell Prolif. 2023 Aug 04:e13528.

PMID: 37539497

FI: 8,5

In-stent restenosis is associated with proliferative skin healing and specific immune and endothelial cell profiles: results from the RACHEL trial.

Lozano Í, Bangueses R, Rodríguez I, Pevida M, Rodríguez-Aguilar R, Rodríguez D, Espasandín-Arias M, Llames S, Meana Á, Suárez A, Rodríguez-Carrio J.

Front Immunol. 2023.14:1138247.

PMID: 37325628

FI: 7,3

Computationally Guided DIW Technology to Enable Robust Printing of Inks with Evolving Rheological Properties.

Maria Luisa Lopez-Donaire, Gonzalo de Aranda-Izuzquiza, Sara Garzon-Hernandez, Javier Crespo-Miguel, Miguel Fernandez-de la Torre, Diego Velasco, Daniel Garcia-Gonzalez.

Adv Mater Technol. Volume8, Issue3. February 10, 2023.

PMID: 10.1002/admt.202201707

FI: 6,8

Driving role of head and neck cancer cell secretome on the invasion of stromal fibroblasts: Mechanistic insights by phosphoproteomics.

Prieto-Fernandez L, Villaronga MLA, Hermida-Prado F, Hijazi M, Montoro-Jimenez I, Pevida M, Llames S, Rodrigo JP, Cutillas P, Calvo F, Garcia-Pedrero JM, Alvarez-Teijeiro S.

Biomed Pharmacother. 2023 Feb.158:114176.

PMID: 36916400

FI: 7,5

BioBlocksLab: A portable DIY Bio Lab using BioBlocks language.

Ma T, Méndez-Merino D, Uría-Regojo G, Sánchez-Fernández C, Giner-Sánchez L, Guerrero-Aspizua S, Quílez-López C, Rodríguez-Patón A.

Methods. 2023 Feb.210:36-43.

PMID: 36641111

FI: 4,8

Improved Tool for Predicting Skin Irritation on Reconstructed Human Epidermis Models Based on Electrochemical Impedance Spectroscopy.

Chacón M, Vázquez N, Alonso-Alonso S, Persinal-Medina M, Llames S, Pevida M, Alcalde I, Merayo-Lloves J, Meana Á.

Biosensors (Basel). 2023 Jan 20.13(2).

PMID: 36831928

FI: 5,4