Data update as of 31/12/2023


6.4.1. GRUPO DE CARDIOLOGÍA-220525-Tuñón-FOTO6.4.1. GRUPO DE CARDIOLOGÍA-220525-Tuñón-FOTO
2023 DATA

Persons in charge

LR

  • Álvaro Aceña Navarro
  • Marta Cortés Canteli

Research

  • Basic
  • Clinical

Location

Cardiology Service 3rd floor.

Hospital Universitario Fundación Jiménez Díaz.

Avda. Reyes Católicos, 2. 28040 Madrid (España).


Key words

Acute myocardial infarction, heart failure, arrhythmias, biomarkers, inflammation, cardio-oncology and cardiotoxicity.


Gender perspective

6.4.1-CARDIOLOGÍA-GÉNERO6.4.1-CARDIOLOGÍA-GÉNERO

Activity summary

We study different cardiac pathologies (coronary heart disease, heart failure, atrial fibrillation, toxicity due to cancer treatments, amyloidosis, etc.) to advance our understanding of their pathophysiology, achieve early diagnosis and adequate prediction of the risk of suffering cardiovascular events, and the development of new treatments. We are working on the study of biomarkers that can predict the development of cardiovascular events, particularly in the areas of inflammation and mineral metabolism, including the effect of vitamin D on the heart, as well as in the area of cholesterol treatment. We are also working on projects that can improve the prognosis of patients with respiratory distress. In addition, we have recently started a pioneering line of research that deepens the understanding of the vascular component of Alzheimer's disease and its relationship with atherosclerosis during asymptomatic stages. Part of these projects are carried out in conjunction with the National Cardiovascular Research Center (CNIC), which allows us to carry out translational research ranging from basic laboratory research to clinical research applied to our patients.


Contributions to society

Our group has a strong dissemination component, aimed at communicating the results of our research to the general public and patients. Borja Ibáñez is the inventor of four patents related to treatments for cardiovascular diseases and their diagnosis by magnetic resonance imaging. Dr. Borja Ibáñez and Dr. José Tuñón have participated in various clinical practice guidelines with the European Society of Cardiology, the former being the coordinator of these guidelines for the treatment of acute myocardial infarction.


Collaborations

Our Area participates in several national and international projects. The large clinical trials we lead are purely scientific in nature, although we also participate in trials related to the pharmaceutical industry. The group leads large European consortia funded by the European Commission through the H2020 programme. European projects such as the ERC-CoG ‘MATRIX’ and the H2020 health project ‘RESILIENCE’ stand out. The latter is coordinated by us, with the collaboration of other hospital areas (Haematology), with the participation of centers from six European countries, as well as the European Society of Cardiology, Philips, and a patients' association. We also have a prominent role in another H2020 health project called ‘RITA-MI2’. The group leads the largest trial worldwide testing the benefit of beta-blockers in patients with infarction and preserved cardiac function (REBOOT trial, with more than 8,000 patients in Spain and Italy). At the basic research level, we are also working on European projects such as ‘BioClotAD’, coordinated by Dr. Marta Cortés Canteli of the Joint Programming Neurodegenerative Disease Research, a joint initiative of the European Union and the Carlos III Health Institute as part of the International Joint Programming Initiatives. This consortium uses the latest molecular imaging technology to develop a radiotracer to non-invasively identify the procoagulant state present in Alzheimer's disease. Borja Ibáñez serves as editor of several journals, notably the high-impact journal JACC, and leads a group in CIBER for Cardiovascular Diseases (CIBERCV).


PhD Theses

6.4.1-CARDIOLOGÍA-TESIS6.4.1-CARDIOLOGÍA-TESIS

List of publications ordered by publication date

Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis.

Iglesies-Grau J, Garcia-Alvarez A, Oliva B, Mendieta G, García-Lunar I, Fuster JJ, Devesa A, Pérez-Herreras C, Fernández-Ortiz A, Brugada R, Ibanez B, Fernandez-Jimenez R, Fuster V.

Cardiovasc Diabetol. 2023 Dec 19.22(1):350.

PMID: 38115031

FI: 9,3


Symptom burden guiding invasive electrophysiological study in paroxysmal supraventricular tachycardia: The believe SVT registry.

Rodriguez Muñoz D, Ramos Jimenez J, Marco Del Castillo Á, Lozano Granero C, García Alberola A, Jiménez Sánchez D, Guntúriz Beltrán C, Ramos Ruiz P, Arias MÁ, Di Nubila B, Betancur A, González Torrecilla E, Dallaglio P, Alonso Fernández P, Ayala More HD, Calero S, Lumia G, Salgado Aranda R, Lázaro Rivera C, Rodríguez Mañero M, Syed A, Arribas Ynsaurriaga F, Salguero-Bodes R.

Am Heart J. 2023 Dec 01.269:15-24.

PMID: 38042457

FI: 4,8


QRS axis and polarity in the inferior leads during left bundle branch pacing: Novel criteria in the search for better results.

Rubio Campal JM, Asís Diaz Cortegana F, Lazaro Rivera C, Garcia Talavera CS, Aguilera Agudo C, Bravo Calero L.

Pacing Clin Electrophysiol. 2023 Dec.46(12):1491-1499.

PMID: 37987482

FI: 1,8


Spanish cardiac catheterization and coronary intervention registry. 32nd official report of the Interventional Cardiology Association of the Spanish Society of Cardiology (1990-2022).

Jurado-Román A, Freixa X, Cid B, Cruz-González I, ACI-SEC, Sarnago Cebada F, Baz JA, Lozano Í, Sabaté M, Jiménez J, Íñigo García LA, Subinas Elorriaga A, Berenguer Jofresa A, Novo García E, Pérez Vizcayno MJ, Carrillo Suárez X, Pinar Bermúdez E, Calviño Santos R, Álvarez Antón S, Trillo Nouche R, Ruíz Arroyo JR, Fernández Cisnal A, Amat-Santos IJ, Jerez Valero M, Rama Merchán JC, Vaquerizo B, Tejada Ponce D, Ruiz Nodar JM, Sánchez Pérez I, Tejedor P, Elizaga J, Jiménez Cabrera FM, Bullones Ramírez JA, Sánchez Aquino R, Portero Pérez MP, Roura G, Mohandes M, Sáez Moreno R, Avanzas P, Caballero J, Torres Bosco AM, Merchán Herrera A, Robles Alonso J, Bosa Ojeda F, García San Román K, Agudelo VH, Martin Lorenzo P, Fernández JC, Pérez de Prado A, Ruiz Quevedo V, Cruz González I, Moreu Burgos J, Ruiz García J, Sánchez Burguillos FJ, Núñez Pernas D, Baello Monge P, Hernando Marrupe L, Franco Peláez JA, Jurado Román A, Pomar Domingo F, Fuertes Ferre G, Pimienta González R, Morales Ponce FJ, Sánchez Recalde Á, Ojeda Pineda S, Frutos Garcia A, Millán Segovia R, Fajardo Molina R, Díez Gil JL, Guisado Rasco A, Gómez Menchero AE, Bosch E, Oteo Domínguez JF, Gutiérrez-Barrios A, Cascón Pérez JD, Casanova Sandoval JM, Fernández Portales J, Rivero Crespo F, Gonzalez Caballero E, Ocaranza Sánchez R, Zueco J, García Del Blanco B, Alonso Briales JH, Sánchez Gila J, Vizcaino Arellano M, Carballo Garrido J, Andraka L, Gómez Jaume A, Merino Otermin Á, Artaiz Urdaci M, Arellano Serrano C, Íñigo García LA, García E, Unzué L, Ruiz Nodar JM, Arzamendi D, Freixa X, Mainar V, Usón M, Palazuelos Molinero J, López Palop R, Bethencourt A, Alegría Barrero E, Camacho Freire SJ, Peña G, Vázquez Álvarez ME, Muñoz Camacho JF, Ramírez Moreno A, Larman Tellechea M, García de la Borbolla Fernández R.

Rev Esp Cardiol (Engl Ed). 2023 Dec.76(12):1021-1031.

PMID: 37863184

FI: 5,9


Natriuretic peptides: Another tool for the management of cancer?

Balaguer J, García-Foncillas J, Tuñón J.

Crit Rev Oncol Hematol. 2023 Nov 28.193:104219.

PMID: 38029944

FI: 6,2


Primary Prevention of Subclinical Atherosclerosis in Young Adults: JACC Review Topic of the Week.

Devesa A, Ibanez B, Malick WA, Tinuoye EO, Bustamante J, Peyra C, Rosenson RS, Bhatt DL, Stone GW, Fuster V.

J Am Coll Cardiol. 2023 Nov 28.82(22):2152-2162.

PMID: 37993206

FI: 24,4


Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years.

Mendieta G, Pocock S, Mass V, Moreno A, Owen R, García-Lunar I, López-Melgar B, Fuster JJ, Andres V, Pérez-Herreras C, Bueno H, Fernández-Ortiz A, Sanchez-Gonzalez J, García-Alvarez A, Ibáñez B, Fuster V.

J Am Coll Cardiol. 2023 Nov 28.82(22):2069-2083.

PMID: 37993199

FI: 24,4


Fibroblast growth factor 23 independently predicts adverse outcomes after an acute coronary syndrome.

Kallmeyer A, Pello A, Cánovas E, Aceña Á, González-Casaus ML, Tarín N, Cristóbal C, Gutiérrez-Landaluce C, Huelmos A, Rodríguez-Valer A, González-Lorenzo Ó, Alonso J, López-Bescós L, Egido J, Mahillo I, Lorenzo Ó, Tuñón J.

ESC Heart Fail. 2023 Nov 10.

PMID: 37950429

FI: 3,8


Treatment For Infected Frozen Elephant Trunk Prosthesis Caused by Propionibacterium acnes: A Surgical Challenge.

Barca LV, Esteban-Lucia L, Tomás-Mallebrera M, Pello-Lázaro A, Aldámiz-Echevarría G.

Braz J Cardiovasc Surg. 2023 Nov 09.39(1):e20230186.

PMID: 37947185

FI: 1,3


Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection.

Heusch G, Andreadou I, Bell R, Bertero E, Botker HE, Davidson SM, Downey J, Eaton P, Ferdinandy P, Gersh BJ, Giacca M, Hausenloy DJ, Ibanez B, Krieg T, Maack C, Schulz R, Sellke F, Shah AM, Thiele H, Yellon DM, Di Lisa F.

Redox Biol. 2023 Nov.67:102894.

PMID: 37839355

FI: 11,4


Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis.

Devesa A, Fuster V, Vazirani R, García-Lunar I, Oliva B, España S, Moreno-Arciniegas A, Sanz J, Perez-Herreras C, Bueno H, Lara-Pezzi E, García-Alvarez A, de Vega VM, Fernández-Friera L, Trivieri MG, Fernández-Ortiz A, Rossello X, Sanchez-Gonzalez J, Ibanez B.

Diabetes Care. 2023 Nov 01.46(11):2050-2057.

PMID: 37713581

FI: 16,2


Dapagliflozin Improved Cardiac Function and Structure in Diabetic Patients with Preserved Ejection Fraction: Results of a Single Centre, Observational Prospective Study.

Cortés M, Lorenzo O, Lumpuy-Castillo J, Martínez-Albaladejo S, Taibo-Urquía M, Pello AM, Bollas AJ, Orejas M, Navas MÁ, Macia E, Martínez ME, Rueda A, Tuñón J.

J Clin Med. 2023 Oct 23.12(20).

PMID: 37892836

FI: 3,9


Impact of the Spanish consensus for improving lipid control on patients admitted for an acute coronary syndrome.

Escobar C, Barrios V, Cequier A, Cosin-Sales J, Seijas J, Doblas JJG, Arrarte V, Tuñon J, Banach M, GOAL investigators.

J Clin Lipidol. 2023.17(6):756-764.

PMID: 37838521

FI: 4,4


LDL's unexpected travel partners in the road to atherosclerosis.

Ben-Aicha S, Ibañez B.

Cardiovasc Res. 2023 Oct 24.119(13):e146-e148.

PMID: 37757454

FI: 10,9


2023 ESC Guidelines for the management of acute coronary syndromes.

Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, Claeys MJ, Dan GA, Dweck MR, Galbraith M, Gilard M, Hinterbuchner L, Jankowska EA, Jüni P, Kimura T, Kunadian V, Leosdottir M, Lorusso R, Pedretti RFE, Rigopoulos AG, Rubini Gimenez M, Thiele H, Vranckx P, Wassmann S, Wenger NK, Ibanez B, ESC Scientific Document Group.

Eur Heart J. 2023 Oct 12.44(38):3720-3826.

PMID: 37622654

FI: 39,3


Isolation of goat milk small extracellular vesicles by novel combined bio-physical methodology.

González MI, Gallardo B, Cerón C, Aguilera-Jiménez E, Cortes-Canteli M, Peinado H, Desco M, Salinas B.

Front Bioeng Biotechnol. 2023.11:1197780.

PMID: 37829562

FI: 5,7


External validation of the InShape II study algorithm for exclusion of chronic thromboembolic pulmonary hypertension in patients with pulmonary thromboembolism.

Joya-Seijo MD, Barrios Garrido-Lestache ME, Rueda-Camino JA, Angelina-García M, Gil-Abizanda AC, Sáenz de Urturi-Rodríguez A, Carrillo Hernández-Rubio J, Del Valle-Loarte P, Salto-Camacho ML, Barba-Martín R.

Rev Clin Esp (Barc). 2023 Sep 16.

PMID: 37722563

FI: 2,9


Longitudinal interplay between subclinical atherosclerosis, cardiovascular risk factors, and cerebral glucose metabolism in midlife: results from the PESA prospective cohort study.

Tristão-Pereira C, Fuster V, Oliva B, Moreno-Arciniegas A, Garcia-Lunar I, Perez-Herreras C, Schöll M, Suárez-Calvet M, Moro MA, Garcia-Alvarez A, Fernandez-Ortiz A, Sanchez-Gonzalez J, Zetterberg H, Blennow K, Ibanez B, Gispert JD, Cortes-Canteli M.

Lancet Healthy Longev. 2023 Sep.4(9):e487-e498.

PMID: 37659430

FI: 13,1


A Program of Life-Style Modification Improved the Body Weight and Micronutrient Status in Obese Patients after Bariatric Surgery.

Crespo-Yanguas M, Lumpuy-Castillo J, Espadas C, Aragón-Valera C, Vázquez C, Lorenzo Ó.

Nutrients. 2023 Aug 30.15(17).

PMID: 37686839

FI: 5,9


Systematic Workflow and Electrogram guidance to reduce X-ray Exposure Time during cryoballoon ablation of atrial fibrillation: the SWEET-Cryo strategy.

Rodríguez Muñoz D, Marco Del Castillo Á, Rajjoub Al-Mahdi EA, Lázaro Rivera C, Guisasola Cienfuegos M, Ramos Jiménez J, Borrego Bernabé L, Arribas Ynsaurriaga F, Salguero-Bodes R.

Europace. 2023 Aug 02.25(9).

PMID: 37497862

FI: 6,1


A tale of pigs, beta-blockers and genetic variants.

Ibáñez B.

Basic Res Cardiol. 2023 Jul 13.118(1):27.

PMID: 37439879

FI: 9,5


Regional differences in STEMI care in Spain. Data from the ACI-SEC Infarction Code Registry.

Rodríguez-Leor, O; Cid-Alvarez, AB; Moreno, R; Rosselló, X; Ojeda, S; Serrador, A; López-Palop, R; Martín-Moreiras, J; Rumoroso, JR; Cequier, A; Ibáñez, B; Cruz-González, I; Romaguera, R; Raposeiras, S; de Prado, AP.

REC-INTERVENTIONAL CARDIOLOGY. 2023. APR-JUN. 5 (2): 118-128.

PMID: 10.24875/RECICE.M22000360

FI: 1,4


Mitral valve replacement in patient with previous Amulet Amplatzer left atrial appendage closure device implantation.

Hernández-Estefanía, R; Aceña, A; Tomás, M; Ibañez, C; García-Vega, MI; Aldamiz-Echevarria, G.

CIRUGIA CARDIOVASCULAR. 2023. MAY-JUN. 30 (3).

PMID: 10.1016/j.circv.2022.07.004

FI: 0,3


Remote Ischemic Conditioning for Anthracycline Cardiotoxicity: The Need to Protect the Most Vulnerable.

Ibáñez B, Gomes-Silva M.

JACC CardioOncol. 2023 Jun.5(3):356-359.

PMID: 37397082

FI: 11,1


Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study.

Sánchez-Cabo F, Fuster V, Silla-Castro JC, González G, Lorenzo-Vivas E, Alvarez R, Callejas S, Benguría A, Gil E, Núñez E, Oliva B, Mendiguren JM, Cortes-Canteli M, Bueno H, Andrés V, Ordovás JM, Fernández-Friera L, Quesada AJ, Garcia JM, Rossello X, Vázquez J, Dopazo A, Fernández-Ortiz A, Ibáñez B, Fuster JJ, Lara-Pezzi E.

Eur Heart J. 2023 Jun 20.

PMID: 37339167

FI: 39,3


Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?

García-Culebras A, Cuartero MI, Peña-Martínez C, Moraga A, Vázquez-Reyes S, de Castro-Millán FJ, Cortes-Canteli M, Lizasoain I, Moro MÁ.

Br J Pharmacol. 2023 Jun 07.

PMID: 37282844

FI: 7,3


Autosomal dominant polycystic kidney disease in young adults.

Martínez V, Furlano M, Sans L, Pulido L, García R, Pérez-Gómez MV, Sánchez-Rodríguez J, Blasco M, Castro-Alonso C, Fernández-Fresnedo G, Robles NR, Valenzuela MP, Naranjo J, Martín N, Pilco M, Agraz-Pamplona I, González-Rodríguez JD, Panizo N, Fraga G, Fernández L, López MT, Dall'Anese C, Ortiz A, Torra R, participants in the REPQRAD.

Clin Kidney J. 2023 Jun.16(6):985-995.

PMID: 37260991

FI: 4,6


Low hemodynamic impact of moderate ARDS caused by SARS-CoV2.

Ioan AM, Gonzalez-Lorenzo O, Kallmeyer Mayor A, Pérez-Calvo C, Santos A.

Med Intensiva. 2023 Jun.47(6):348-350.

PMID: 37250856

FI: 3


Ivabradine for controlling heart rate in permanent atrial fibrillation: A translational clinical trial.

Fontenla A, Tamargo J, Salgado R, López-Gil M, Mejía E, Matía R, Toquero J, Montilla I, Rajjoub EA, García-Fernandez FJ, Miracle A, Rey JR, Bueno H, BRAKE-AF Study Investigators.

Heart Rhythm. 2023 Jun.20(6):822-830.

PMID: 37245897

FI: 5,5


Do Women Physicians Accept and Follow Heart Failure Guidelines More Than Men?

Álvarez-García J, Cristo Ropero MJ, Iniesta Manjavacas ÁM, Díez-Villanueva P, Esteban-Fernández A, de Juan Bagudá J, Rivas-Lasarte M, Taibo Urquía M, Górriz-Magaña J, Cobo Marcos M, Goirigolzarri-Artaza J, Iglesias Del Valle D, Bover Freire R, Beltrán Herrera C, Villa A, Campuzano Ruiz R, Martínez-Sellés M.

Curr Heart Fail Rep. 2023 Jun.20(3):151-156.

PMID: 37022560

FI: 3,5


Management of non-hepatic distant metastases in neuroendocrine neoplasms.

Lacalle-González C, Estrella Santos A, Landaeta Kancev LC, Castellano VM, Macia Palafox E, Paniagua Ruíz A, Luna Tirado J, Martínez-Amores B, Martínez Dhier L, Lamarca A.

Best Pract Res Clin Endocrinol Metab. 2023 May 10:101784.

PMID: 37270333

FI: 7,4


Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart.

Hang T, Lumpuy-Castillo J, Goikoetxea-Usandizaga N, Azkargorta M, Aldámiz G, Martínez-Milla J, Forteza A, Cortina JM, Egido J, Elortza F, Martínez-Chantar M, Tuñón J, Lorenzo Ó.

Int J Mol Sci. 2023 May 11.24(10).

PMID: 37239977

FI: 5,6


Cardiovascular toxicity of checkpoint inhibitors: review of associated toxicity and design of the Spanish Immunotherapy Registry of Cardiovascular Toxicity.

Zatarain-Nicolás E, Martín P, Márquez Rodas I, Virizuela J, Martín García A, Mitroi C, Cosín Sales J, Barrios V, Sánchez-Cabo F, Ibañez B, de Castro Carpeño J, López Fernández T.

Clin Transl Oncol. 2023 May 25.

PMID: 37227656

FI: 3,4


The role of bioimpedance analysis in overweight and obese patients with acute heart failure: a pilot study.

Venegas-Rodríguez A, Pello AM, López-Castillo M, Taibo Urquía M, Balaguer-Germán J, Munté A, González-Martín G, Carriazo-Julio SM, Martínez-Milla J, Kallmeyer A, González Lorenzo Ó, Gaebelt Slocker HP, Tuñón J, González-Parra E, Aceña Á.

ESC Heart Fail. 2023 May 24.

PMID: 37226407

FI: 3,8


Study about the Manchester Triage System subtriage in patients that visited the Emergency Department due to headache.

García-Azorín D, Abelaira-Freire J, Rodriguez-Adrada E, González-García N, Guerrero ÁL, Porta-Etessam J, Martín-Sánchez FJ.

Neurologia (Engl Ed). 2023 May.38(4):270-277.

PMID: 37030513

FI: 3,9


Motivational interview and imaging of subclinical atherosclerosis for cardiovascular disease prevention: a winning combination?

Garcia-Lunar I, Ibanez B, Fuster V.

Eur Heart J. 2023 May 01.44(17):1575-1576.

PMID: 36958859

FI: 39,3


Effect of Flu Vaccination on Severity and Outcome of Heart Failure Decompensations.

Miró Ò, Ivars N, Lopez-Ayala P, Gil V, Llauger L, Alquézar-Arbé A, Jacob J, Rodríguez-Adrada E, Tost J, Mir M, Gil C, Sánchez S, Aguirre A, Martín E, Alonso MI, Garrido JM, López-Grima ML, Lucas-Imbernon FJ, Sánchez C, Escoda R, Gil A, Espinosa B, Wussler D, Peacock WF, Mueller C, Llorens P, ICA-SEMES group.

J Card Fail. 2023 May.29(5):734-744.

PMID: 36706976

FI: 6,7


Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.

Romero-Miguel D, Casquero-Veiga M, Fernández J, Lamanna-Rama N, Gómez-Rangel V, Gálvez-Robleño C, Santa-Marta C, Villar CJ, Lombó F, Abalo R, Desco M, Soto-Montenegro ML.

Antioxidants (Basel). 2023 Apr 20.12(4).

PMID: 37107344

FI: 7


Ischemic postconditioning fails to reduce infarct size in pig models of intermediate and prolonged ischemia.

Nuche, J; Galán-Arriola, C; Fernández-Jiménez, R; Verdejo, MIH; Pastor, VIG; Vazirani, R; Lanaspa, A; Anguita-Gámez, M; Martín, GJL; Sánchez-González, J; Ibáñez, B.

REC-INTERVENTIONAL CARDIOLOGY. 2023. JAN-MAR. 5 (1): 29-37.

PMID: 10.24875/RECICE.M22000333

FI: 1,4


Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents.

Real C, Párraga R, Pizarro G, García-Lunar I, González-Calvo E, Martínez-Gómez J, Sánchez-González J, Sampedro P, Sanmamed I, De Miguel M, De Cos-Gandoy A, Bodega P, Ibanez B, Santos-Beneit G, Fuster V, Fernández-Jiménez R.

EClinicalMedicine. 2023 Mar.57:101885.

PMID: 37064511

FI: 15,1


Paradigm Shift: Cardiovascular Health in the Elderly-Beware of the Brain.

Fuster V, Turco JV, Cortes-Canteli M.

J Am Coll Cardiol. 2023 Mar 28.81(12):1214-1215.

PMID: 36948739

FI: 24,4


Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome.

Capellán R, Orihuel J, Marcos A, Ucha M, Moreno-Fernández M, Casquero-Veiga M, Soto-Montenegro ML, Desco M, Oteo-Vives M, Ibáñez-Moragues M, Magro-Calvo N, Morcillo MÁ, Ambrosio E, Higuera-Matas A.

Transl Psychiatry. 2023 Mar 08.13(1):84.

PMID: 36890154

FI: 6,8


Response to the letter of Dr. Ian Desouza.

Farré J, Rubio JM, Sternick EB.

Indian Pacing Electrophysiol J. 2023.23(2):54-55.

PMID: 36754209

FI: 0


Absence of High Lipoprotein(a) Levels Is an Independent Predictor of Acute Myocardial Infarction without Coronary Lesions.

Kallmeyer A, Pello Lázaro AM, Blanco-Colio LM, Aceña Á, González-Lorenzo Ó, Tarín N, Cristóbal C, Gutiérrez-Landaluce C, Huelmos A, Lumpuy-Castillo J, López-Castillo M, Montalvo JM, Alonso Martin JJ, López-Bescós L, Egido J, Lorenzo Ó, Tuñón J.

J Clin Med. 2023 Jan 26.12(3).

PMID: 36769608

FI: 3,9


Spontaneous Variation of Ventriculo-Atrial Interval after Tachycardia Induction: Determinants and Usefulness in the Diagnosis of Supraventricular Tachycardias with Long Ventriculoatrial Interval.

Durán-Bobin O, Hernández J, Moríñigo J, Sánchez-García M, Bravo L, Fernández-Portales J, Oterino A, Cruz A, González-Juanatey C, Sánchez PL, Jiménez-Candil J.

J Clin Med. 2023 Jan 04.12(2).

PMID: 36675339

FI: 3,9


C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease.

Sierra-Magro A, Bartolome F, Lozano-Muñoz D, Alarcón-Gil J, Gine E, Sanz-SanCristobal M, Alonso-Gil S, Cortes-Canteli M, Carro E, Pérez-Castillo A, Morales-García JA.

Int J Mol Sci. 2023 Jan 11.24(2).

PMID: 36674978

FI: 5,6


Oral anticoagulants: A plausible new treatment for Alzheimer's disease?

Toribio-Fernandez R, Ceron C, Tristão-Pereira C, Fernandez-Nueda I, Perez-Castillo A, Fernandez-Ferro J, Moro MA, Ibañez B, Fuster V, Cortes-Canteli M.

Br J Pharmacol. 2023 Jan 12.

PMID: 36633908

FI: 7,3


Infections and Cardiovascular Disease: JACC Focus Seminar 1/4.

Farina JM, Liblik K, Iomini P, Miranda-Arboleda AF, Saldarriaga C, Mendoza I, Zaidel EJ, Rubio-Campal JM, Sosa-Liprandi A, Baranchuk A.

J Am Coll Cardiol. 2023 Jan 03.81(1):71-80.

PMID: 36599613

FI: 24,4


Projects, contracts and observational studies

PUBLICS

Sources of public funding for projects being developed at the IIS-FJD:

_FUENTES DE FINANCIACIÓN PÚBLICA-02_FUENTES DE FINANCIACIÓN PÚBLICA-02

REFERENCE

PROJECT TITLE

PRINCIPAL RESEARCHER

TYPE OF PROJECT

TOTAL FUNDING

MATRIX - ERC-2018-COG

NOVEL MITOCHONDRIA-TARGETED THERAPIES FOR CÁNCER TREATMENT-INDUCED CARDIOTOXICITY

IBAÑEZ CABEZA BORJA

PROYECTO EUROPEO H2020

525.937,50 €

PROFID

IMPLEMENTATION OF PERSONALISED RISK PREDICTION AND PREVENTION OF SUDDEN CARDIAC DEATH AFTER MYOCARDIAL INFARCTION

IBAÑEZ CABEZA BORJA

PROYECTO EUROPEO H2020

83.500,00 €

RITA-MI 2

RITUXIMAB IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: A PHASE 2 PLACEBO-CONTROLLED RANDOMISED

IBAÑEZ CABEZA BORJA

PROYECTO EUROPEO H2020

383.500,00 €

CB16/11/00358

GRUPO DE INVESTIGACION DEL CIBER DE ENFERMEDADES CARDIOVASCULARES

IBAÑEZ CABEZA BORJA

CIBER

0,00 €

PI19/00655

DIAGNÓSTICO PRECOZ DE AMILOIDOSIS CARDIACA Y CARDIOMIOPATÍA ASOCIADA A GAMMAPATÍA MONOCLONAL COMO VENTANA DE OPORTUNIDAD.

ACEÑA NAVARRO ALVARO

PROYECTO FIS

89.540,00 €

AC20/00077

DESARROLLO DE UN BIOMARCADOR DE NEUROIMAGEN PARA DETECTAR EL ESTADO PROCOAGULANTE EN LA ENFERMEDAD DE ALZHEIMER

CORTES CANTELI MARTA

ACCIONES DE PROGRAMACIÓN CONJUNTA INTERNACIONAL

153.116,40 €

PI20/00819

IMPACTO DE LA ENFERMEDAD CARDIOVASCULAR SUBCLÍNICA EN EL METABOLISMO, PERFUSIÓN Y FUNCIÓN CEREBRAL.

CORTES CANTELI MARTA

PROYECTO FIS

75.020,00 €

PI20/00923

PAPEL DE LA PROPROTEÍNA CONVERTASA SUBTILISINA–KEXINA TIPO 9 (PCSK9) EN LA RESPUESTA INFLAMATORIA EN LA ENFERMEDAD CORONARIA

TUÑON FERNANDEZ JOSE

PROYECTO FIS

96.800,00 €

RTC2019-006826-1

DESARROLLO DE NUEVOS MEDICAMENTOS BASADOS EN ANÁLOGOS DE VIT D PARA EL TRATAMIENTO DE LA DEFICIENCIA DE VITAMINA D Y PATOLOGÍAS ASOCIADAS (IFEROL).

TUÑON FERNANDEZ JOSE

PROYECTO PLAN NACIONAL

209.613,82 €

CPII21/00007

CONTRATO MIGUEL SERVET II - MARTA CORTÉS CANTELI

CORTES CANTELI MARTA

CONTRATO MIGUEL SERVET II

101.250,00 €

FI21/00209

CONTRATO PFIS - CRISTINA ESPADAS ÑÍGUEZ

TUÑON FERNANDEZ JOSE

CONTRATO PREDOCTORAL PFIS

89.900,00 €

PRIVATE

REFERENCE

PROJECT TITLE

PRINCIPAL RESEARCHER

TYPE OF PROJECT

NIPAD

DEVELOPMENT OF MULTIMODAL NEUROIMAGING BIOMARKERS OF THE PRO-COAGULANT STATE IN ALZHEIMER’S DISEASE

CASQUERO VEIGA MARTA

PROYECTOS COMPETITIVOS PRIVADOS

SEC/FEC-INV-CLI 23/13

PAPEL DEL FACTOR DE CRECIMIENTO DE FIBROBLASTOS-23 EN EL DIAGNÓSTICO Y PRONÓSTICO DE LA INSUFICIENCIA CARDIACA.

TUÑON FERNANDEZ JOSE

PROYECTOS COMPETITIVOS PRIVADOS

227874/001

COLABORACIÓN CIENTÍFICA EN DIVERSOS PROYECTOS DEL ÁREA CARDIOVASCULAR

CORTES CANTELI MARTA

PROYECTOS PRIVADOS NO COMPETITIVOS

PIC168-22_FJD

REGISTRO MULTICENTRICO ESPAÑOL SOBRE LA INSUFICIENCIA TRISCUSPIDE GRAVE

TUÑON FERNANDEZ JOSE

PROYECTOS PRIVADOS NO COMPETITIVOS

EOH004-21_FJD

IMPACTO DEL CONSENSO ESPAÑOL PARA LA MEJORA DE LOS OBJETIVOS LDL COLESTEROL DESPUÉS DE UN SÍNDROME CORONARIO AGUDO

TUÑON FERNANDEZ JOSE

ESTUDIOS OBSERVACIONALES

12916/003

CURSO DE URGENCIAS CARDIOLÓGICAS

PELLO LAZARO ANA MARIA

CURSOS/ACTIVIDADES FORMATIVAS

4381/003

CURSO DE ESPECIALIZACIÓN PARA ENFERMERIA EN ELECTROFISIOLOGIA Y DISPOSITIVOS IMPLANTABLES

RUBIO CAMPAL JOSE MANUEL

CURSOS/ACTIVIDADES FORMATIVAS

10733/001

SERVICIO DE CARDIOLOGIA_BORJA IBAÑEZ

IBAÑEZ CABEZA BORJA

OTRAS ACTIVIDADES DE INVESTIGACION

4768/008

SERVICIO CARDIOLOGIA-TUÑON

TUÑON FERNANDEZ JOSE

OTRAS ACTIVIDADES DE INVESTIGACION


Clinical trials

The clinical trials listed below were in the recruitment phase in 2023. If you are interested in participating in any of the currently open trials, more information is available on the website (https://ensayos.quironsalud.es/)

EudraCT Number

TITLE

PHASE

MC1

INT2

PRINCIPAL RESEARCHER

2020-000840-75

ESTUDIO EN FASE IIB, ALEATORIADO, DOBLE CIEGO, CONTROLADO CON PLACEBO, DE GRUPOS PARALELOS PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE MEDI6570 EN PARTICIPANTES CON UN INFARTO DE MIOCARDIO PREVIO, INFLAMACIÓN PERSISTENTE Y NIVELES ELEVADOS DE PROHORMONA N-TERMINAL DEL PÉPTIDO NAUTRIURÉTICO CEREBRAL

II

SI

SI

TUÑON FERNANDEZ JOSE

2022-501893-21

RITUXIMAB IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION. A PHASE 2 PLACEBO-CONTROLLED RANDOMIZED CLINICAL TRIAL

II

SI

SI

TUÑON FERNANDEZ JOSE

2019-002873-80

ENSAYO CLÍNICO UNICÉNTRICO, ABIERTO, NO CONTROLADO, PARA EVALUAR LAS REPERCUSIONES MORFOLÓGICAS, BIOQUÍMICAS Y FUNCIONALES DEL TRATAMIENTO CON DIFLUNISAL EN PACIENTES CON AMILODOSIS CARDIACA POR TRANSTIRETINA

II/III

NO

NO

ACEÑA NAVARRO ALVARO

2020-000941-15

ESTUDIO ALEATORIZADO Y DOBLE-CIEGO PARA VALORAR EL BENEFICIO DE COLCHICINA EN PACIENTES CON IC AGUDA

III

SI

NO

IBAÑEZ CABEZA BORJA

2021-001627-40

UN ENSAYO DE FASE III, ALEATORIZADO, DOBLE CIEGO Y CONTROLADO CON PLACEBO DE UNA SOLUCION PARA INHALACION DE ACETATO DE FLECAINIDA PARA LA CARDIOVERSION DE LA FIBRILACION AURICULAR SINTOMATICA DE INICIO RECIENTE A RITMO SINUSAL (RESTORE-1)

III

SI

SI

RUBIO CAMPAL JOSE MANUEL

2014-004512-11

ENSAYO CLÍNICO MULTICÉNTRICO, ALEATORIZADO, DOBLE CIEGO, CONTROLADO CON PLACEBO, PARA EVALUAR EL EFECTO DE LA VITAMINA D SOBRE EL REMODELADO VENTRICULAR EN PACIENTES CON INFARTO AGUDO DE MIOCARDIO: ENSAYO VITDAMI (VITAMIN D IN ACUTE MYOCARDIAL INFARCTION)

III

SI

NO

TUÑON FERNANDEZ JOSE

2017-002644-32

ESTUDIO ALEATORIZADO, DOBLE CIEGO, CONTROLADO CON PLACEBO, DE GRUPOS PARALELOS MULTICÉNTRICO, PARA DEMOSTRAR LOS EFECTOS DE SOTAGLIFLOZINA SOBRE LOS EVENTOS CARDIOVASCULARES Y RENALES EN PACIENTES CON DIABETES TIPO 2, FACTORES DE RIESGO CARDIOVASCULAR Y FUNCIÓN RENAL MODERADAMENTE REDUCIDA

III

SI

SI

TUÑON FERNANDEZ JOSE

2019-001076-11

ENSAYO MULTICÉNTRICO, ALEATORIZADO, DOBLE CIEGO, CONTROLADO CON PLACEBO PARA EVALUAR EL EFECTO DE LA DISMINUCIÓN DE LA LIPOPROTEÍNA (A) CON TQJ230 SOBRE LOS A CARDIOVASCULARES MAYORES EN PACIENTES CON ENFERMEDAD CARDIOVASCULAR (ECV) ESTABLECIDA

III

SI

SI

TUÑON FERNANDEZ JOSE

2021-002006-27

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER TRIAL, ASSESSING THE IMPACT OF INCLISIRAN ON MAJOR ADVERSE CARDIOOVASCULAR EVENTS IN PARTICIPANTS WITH ESTABLISHED CARDIOVASCULAR DISEASE (VICTORION-2 PREVENT)

III

SI

SI

TUÑON FERNANDEZ JOSE

2019-002852-17

EFICACIA Y SEGURIDAD DE LA FUROSEMIDA INTRAVENOSA ADMINISTRADA CON SUERO SALINO HIPERTÓNICO EN EL HOSPITAL DE DÍA DE INSUFICENCIA CARDIACA

IV

NO

NO

BARRIOS GARRIDO-LESTACHE MARÍA ELVIRA

2021-001905-66

ENSAYO CLINICO ALEATORIZADO PARA EVALUAR EL EFECTO DE LOS BETABLOQUEANTES Y ANTIAGREGANTES PLAQUETARIOS EN PACIENTES CON DISECCION ESPONTANEA DE LA ARTERIA CORONARIA

IV

SI

NO

FRANCO PELAEZ JUAN ANTONIO

2017-002485-40

TRATAMIENTO CON BETABLOQUEANTES TRAS INFARTO DE MIOCARDIO SIN FRACCIÓN DE EYECCIÓN REDUCIDA

IV

SI

NO

IBAÑEZ CABEZA BORJA

2017-002799-18

BENEFICIO DEL BLOQUEO DEL SISTEMA RENINA-ANGIOTENSINA SOBRE LA EVOLUCIÓN CLÍNICA Y EL REMODELADO VENTRICULAR TRAS LA COLOCACIÓN DE UNA PRÓTESIS PERCUTÁNEA AÓRTICA

IV

NO

NO

IBAÑEZ CABEZA BORJA

2020-003930-18

DAPAGLIFLOZINA DESPUÉS DEL IMPLANTE DE PRÓTESIS VALVULAR AÓRTICA PERCUTÁNEA

IV

SI

NO

IBAÑEZ CABEZA BORJA

2021-001327-41

RETIRADA DE TRATAMIENTO FARMACOLOGICO EN PACIENTES RESPONDEDORES A TERAPIA DE RESINCRONIZACION CARDIACA: ESTUDIO ABIERTO Y ALEATORIZADO

IV

NO

NO

IBAÑEZ CABEZA BORJA

2014-001397-33

APIXABÁN PARA LA REDUCCIÓN DEL TROMBOEMBOLISMO EN PACIENTES CON FIBRILACIÓN AURICULAR SUBCLÍNICA DETECTADA POR UN DISPOSITIVO

IV

SI

SI

RUBIO CAMPAL JOSE MANUEL

NA

SYNCAV: ESTUDIO POST-COMERCIALIZACIÓN (CRD-973)

IV

SI

SI

RUBIO CAMPAL JOSE MANUEL

NA

ABLACION DE SUSTRATO COMO TRATAMIENTO CONCOMITANTE EN LA TAQUICARDIA AURICULAR MACRORREENTRANTE DE AURICULA IZQUIERDA. PROYECTO SLICE LAMRT (SUBSTRATE ABLATLON AS CONCOMITANT TREATMENT FOR LEFT ATRIAL MACROREENTRANT TACHYCARDIA)

IV

NO

NO

RUBIO CAMPAL JOSE MANUEL

NA

ESTUDIO BOCADOS-IC: ENSAYO CLÍNICO ALEATORIZADO PROSPECTIVO MULTCÉNTRICO SOBRE EL ABORDAJE NUTRICIONAL EN ADULTOS SEGUIDOS EN HOSPITALES ESPAÑOLES POR INSUFICIENCIA CARDIACA

IV

NO

NO

TABIO URQUIA MIKEL

NA

IMPACTO DEL PRECONDICIONAMIENTO ISQUÉMICO REMOTO EN LA PREVENCIÓN DEL ESPASMO DE LA ARTERIA RADIAL EN PACIENTES SOMETIDOS A ANGIOGRAFÍA CORONARIA. (PIREA STUDY)

N/A

SI

NO

IBAÑEZ CABEZA BORJA

NA

ESTIMULACION DEL SISTEMA DE CONDUCCIÓN Y ABLACION DEL NODO AURICULOVENTRICULAR (AV) EN PACIENTES CON INSUFICIENCIA CARDIACA (IC), FRACCION DE EYECCION DE VENTRICULO IZQUIERDO (FEVI) >40% Y FIBRILACION AURICULAR (FA) PERMANENTE

N/A

SI

NO

LAZARO RIVERA CARLA

NA

EFICACIA DE CHOQUE DE CARDIOVERSIÓN/DESFIBRILACIÓN, UN ESTUDIO ALEATORIZADO QUE COMPARA LA PENDIENTE FIJA Y LA ANCHURA DE IMPULSO FIJA EN UNA POBLACIÓN GENERAL CON DESFIBRILADOR AUTOMÁTICO IMPLANTABLE. ESTUDIO EFICAZ

N/A

SI

NO

RUBIO CAMPAL JOSE MANUEL

NA

ENSAYO CLINICO ALEATORIZADO SOBRE EL EFECTO DEL PRECONDICIONAMIENTO ISQUÉMICO Y LA PUNCION ECOGUIADA EN LA TASA DE EXITO DE LA CANALIZACION DE LA ARTERIA RADIAL EN PACIENTES QUE VAN A SER SOMETIDOS A UN CATETERISMO CARDIACO

N/A

NO

NO

SANCHEZ GONZALEZ JUAN CARLOS

MC1: Multicéntrico INT2: Internacional