Data update as of 31/12/2023


6.4.5. GRUPO ASOCIADO DE UROLOGÍA-220525-María-FOTO6.4.5. GRUPO ASOCIADO DE UROLOGÍA-220525-María-FOTO
2023 DATA

Persons in charge


Research

  • Clinical

Location

Urology Area, 1st floor.

Hospital Universitario Fundación Jiménez Díaz.

Avda. Reyes Católicos, 2. 28040 Madrid (España).


Key words

Oncological Urology, Functional Urology, Urodynamics and Pelvic Floor, Urinary Incontinence, Urinary Infections, Surgical Techniques and Medical Devices. Prognostic and predictive factors in cancer.


Gender perspective

6.4.5-UROLOGÍA-GÉNERO6.4.5-UROLOGÍA-GÉNERO


Activity summary

Through numerous projects of varying types, the Urology Department's research focuses on developing new surgical procedures, drugs and medical devices applied to urological oncology and benign urogenital pathology. We explore the application of regenerative medicine in functional urology and andrology, and of genetic and immunohistochemical analyses to identify biomarkers in urological cancers.


Contributions to society

Our participation in clinical and translational research projects allows us to drive innovation in new products, drugs and surgical techniques. We apply this knowledge to medical practice and provide accurate and personalised medical care in the prevention, diagnosis and treatment of urological diseases. We actively participate in international initiatives to share knowledge and medical technology, thus strengthening our contribution to society.


Collaborations

We seek out active projects, develop new lines of research and increase our collaborative network to improve our knowledge of genitourinary disorders and improve healthcare for our patients.

We currently collaborate with independent researchers, research groups, universities and scientific societies, such as:

  • The Advanced Therapies Group of the IIS-FJD in developing innovative therapies for urological pathologies such as urinary incontinence and erectile dysfunction with two research projects in the field of regenerative medicine.
  • The Spanish Association of Urology (AEU). Through the AEU’s Research Platform for Multi-center Studies, we are sponsors of the national registry of ‘Adjustable sling treatment for male post-surgical stress urinary incontinence in Spain’, and collaborating researchers in several uro-oncology research projects.
  • The Foundation for Urology Research (FIU) in a clinical study aimed at treating high-risk non-muscle infiltrating bladder tumours with IMUNO BCG Moreau RJ as prophylaxis for recurrence and progression.
  • European Uro-Oncology Group (EUOG): We are participating in a Phase II, non-commercial clinical trial on the management of urothelial carcinoma of the upper urinary tract.
  • UNICANCER, Health Cooperative Group (Groupement de Coopération Sanitaire-GCS) in the ALBAN clinical trial: An open label, randomised, phase III trial, evaluating efficacy of Atezolizumab in addition to one year BCG (Bacillus CaLmette- Guerin) bladder instillation in BCG-naïve patients with high-risk non-muscle invasive Bladder cancer
  • The ALIANZA VHL (Spanish von Hippel-Lindau Family Association). We collaborate with the donation of renal tumour primary cell cultures for the search of biomarkers in patients with von Hippel-Lindau disease.
  • The Latin American Renal Cancer Group (LARCG): We collaborate on an international registry of renal tumours.
  • The Department of Pharmacology and Therapeutics. Faculty of Medicine, UAM: since 2008 we have participated in several research projects (4) related to the surgically donated adrenal gland, two of which have been funded by the Ministry of Economy and Competitiveness over the last ten years.

The Urology Area also collaborates with HUFJD’s Oncology and Nephrology Area in the donation of samples for the following studies and research projects:

  • Study: Multi Omics Data Cancer Diagnostics Therapies (TITANIA Study)
  • Study: FJD-ENBIBA: EUROPEAN NEPHRECTOMY BIO-BANK.

PhD Theses

6.4.5-UROLOGÍA-TESIS6.4.5-UROLOGÍA-TESIS


List of publications ordered by publication date

Spectral characterization of renal calculi collected from population in downtown Madrid (Spain).

González-Enguita C, Garcia-Giménez R, Garcia-Guinea J, Correcher V.

Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 05.304:123395.

PMID: 37716040

FI: 4,4


Performance of a multidisciplinary robotic surgery program at a university hospital (2012-2022).

Sanchez-Encinas M, Rey-Biel J, Alias D, Noguero-Meseguer R, Granell J, Muguruza I, Herrero A, Ayala JL, Barba R.

J Robot Surg. 2023 Dec.17(6):2869-2874.

PMID: 37804394

FI: 2,3


Environmental Conditions as Determinants of Kidney Stone Formation.

González-Enguita C, Bueno-Serrano G, López de Alda-González A, García-Giménez R.

ACS Appl Bio Mater. 2023 Nov 20.6(11):5030-5036.

PMID: 37913796

FI: 4,7


Women in urology: what is their current situation in Spain?

Seguí-Moya E, Amorós-Torres A, Centeno-Álvarez C, Gutiérrez-Zurimendi G, Nuno de la Rosa I, Escudero-Fontano E, Sierra Del Río A, Moreno-Fontela MP, Sánchez-García M, Mir-Maresma MC, Musquera-Felip M, Ribal-Caparrós MJ, López-Díez E, González-Enguita C.

Actas Urol Esp (Engl Ed). 2023 Sep.47(7):462-469.

PMID: 37442224

FI: 1,1


Results of Adjustable Trans-Obturator Male System in Patients with Prostate Cancer Treated with Prostatectomy and Radiotherapy: A Multicenter Study.

Angulo JC, Téllez C, Giammò A, González-Enguita C, Schoenburg S, Queissert F, Szczesniewski J, González R, Romero A, Gonsior A, Martins FE, Antunes-Lopes T, Cruz F, Rourke K.

J Clin Med. 2023 Jul 17.12(14).

PMID: 37510835

FI: 3,9


Is Extracorporeal Shock Wave Lithotripsy a Treatment Option for Renal Colic?

Alcoba García MDP, Bueno Serrano G, Tabares Jiménez J, González López R, Coloma Ruíz L, González Enguita C.

Arch Esp Urol. 2023 May.76(3):175-181.

PMID: 37340522

FI: 0,5


BCG shortage for intravesical instillation is associated with early tumoral recurrence in patients with high-risk non-muscle invasive bladder tumours.

Pérez-Aizpurua X, Monzó-Gardiner JI, Maqueda-Arellano J, Buendía-González E, Cuello-Sánchez L, Tufet I Jaumot JJ, Alonso-Román J, Gómez-Jordana Mañas B, Ruiz de Castroviejo Blanco J, Osorio Ospina F, Cabello Benavente R, González-Enguita C.

Actas Urol Esp (Engl Ed). 2023 May.47(4):250-258.

PMID: 36754206

FI: 1,1


Animal model assessment of a new design for a coated mitomycin-eluting biodegradable ureteral stent for intracavitary instillation as an adjuvant therapy in upper urothelial carcinoma.

Soria F, Delacruz JE, Aznar-Cervantes SD, Aranda J, Martínez-Pla L, Cepeda M, Pérez-Lanzac A, Bueno G, Sánchez-Margallo FM.

Minerva Urol Nephrol. 2023 Apr.75(2):194-202.

PMID: 36999837

FI: 4,9


Evolution and current status of the management of functional and pelvic floor pathology in the hospitals of the Community of Madrid.

Quintana Franco LM, González López R, Garde García H, Díez Rodríguez JM, González Enguita C.

Actas Urol Esp (Engl Ed). 2023 Apr.47(3):187-192.

PMID: 36731821

FI: 1,1


Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment.

Pérez-Aizpurua X, Garranzo-Ibarrola M, Simón-Rodríguez C, García-Cardoso JV, Chávez-Roa C, López-Martín L, Tufet I Jaumot JJ, Alonso-Román J, Maqueda-Arellano J, Gómez-Jordana B, Ruiz de Castroviejo-Blanco J, Osorio-Ospina F, González-Enguita C, García-Arranz M.

Life (Basel). 2023 Feb 11.13(2).

PMID: 36836859

FI: 3,2


Natural history of renal angiomyolipoma in a high-volume center: our experience during more than 15 years of follow up.

Aumatell J, Schwartzmann I, Bravo-Balado A, Subiela JD, Farré A, Moncada E, Martínez MJ, Palou J, Breda A, Ponce de León Roca J.

Int Urol Nephrol. 2023 Dec 12.

PMID: 38085409

FI: 2


Systematic Review and Meta-analysis of Minimally Invasive Procedures for Surgical Inguinal Nodal Staging in Penile Carcinoma.

Greco I, Fernandez-Pello S, Sakalis VI, Barreto L, Albersen M, Ayres B, Antunes Lopes T, Campi R, Crook J, García Perdomo HA, Johnstone PAS, Kailavasan M, Manzie K, Marcus JD, Necchi A, Oliveira P, Osborne J, Pagliaro LC, Parnham AS, Pettaway CA, Protzel C, Rumble RB, Sachdeva A, Sanchez Martinez DF, Zapala Ł, Tagawa ST, Spiess PE, Brouwer OR.

Eur Urol Focus. 2023 Dec 08.

PMID: 38071107

FI: 5,4


Clinical Usefulness of Prostate-specific Membrane Antigen-ligand Positron Emission Tomography/Computed Tomography for the Detection of Prostate Cancer Biochemical Recurrence after Primary Radiation Therapy in Patients with Prostate-specific Antigen Below the Phoenix Threshold: Systematic Review and Meta-analysis.

Subiela JD, Gomis Sellés E, Maldonado A, Lopez Campos F, Aumatell Ovide J, Ajuria Illarramendi O, González-Padilla DA, Gajate P, Ortega Polledo LE, Alonso Y Gregorio S, Guerrero-Ramos F, Gómez Dos Santos V, Rodríguez-Patrón R, Calais J, Kishan AU, Burgos Revilla FJ, Couñago F.

Clin Oncol (R Coll Radiol). 2023 Sep 27.

PMID: 37802722

FI: 3,4


Projects, contracts and observational studies

PUBLIC

Sources of public funding for projects being developed at the IIS-FJD:

_FUENTES DE FINANCIACIÓN PÚBLICA-02_FUENTES DE FINANCIACIÓN PÚBLICA-02

NA

PRIVATE

REFERENCE

PROJECT TITLE

PRINCIPAL RESEARCHER

TYPE OF PROJECT

4772/016

PROYECTO EDUCATIVO UROLOGÍA PARA PACIENTES

GONZALEZ ENGUITA CARMEN

PROYECTOS PRIVADOS NO COMPETITIVOS

PIC106-22_FJD

REAL WORLD EVIDENCE OBSERVATIONAL STUDY TO EVALUATE PERFORMANCE ANDSAFETY OF INTRAVESICAL SODIUM
HYALURONATE (CYSTISTAT®) IN THE TREATMENT OF PATIENTS WITHINTERSSTITIAL CYSTITIS (IC)/BLADDER PAIN SYNDROME
(BPS)

GONZALEZ LOPEZ RAQUEL

PROYECTOS PRIVADOS NO COMPETITIVOS

PIC139-23_HRJC

BARVANA LONG: PROSPECTIVE, MULTICENTER, SINGLE-ARM, CONTROLLED STUDY ON THE PERFORMANCE OF SYMMCORA LONG-TERM BIDIRECTIONAL BARBED SUTURE FOR VESICOURETHRAL ANASTOMOSIS IN PATIENTS UNDERGOING ROBOT ASSISTED RADICAL PROSTATECTOMY.

SANCHEZ ENCINAS MIGUEL

PROYECTOS PRIVADOS NO COMPETITIVOS

EOH029-23_FJD

DEVELOPMENT AND VALIDATION OF A PSYCHOLOGICAL DISTRESS SCREENING QUESTIONNAIRE (PROM) FOR PARTICIPANTS WITH PROSTATE CANCER: A CROSS-SECTIONAL OBSERVATIONAL STUDY (HRQOL CAP)

GONZALEZ ENGUITA CARMEN

ESTUDIOS OBSERVACIONALES

EOH049-23_FJD

PATRONES DE TRATAMIENTO Y SEGUIMIENTO PROLONGADO DE LOS PACIENTES CON CÁNCER DE PRÓSTATA QUE RECIBIERON DAROLUTAMIDA EN EL ENSAYO ARAMIS - PARASEC

GONZALEZ ENGUITA CARMEN

ESTUDIOS OBSERVACIONALES

4772/014

11ª EDICIÓN CURSO TX-THIEL: TRASPLANTE RENAL: TÉCNICA Y FUNDAMENTOS. CIRUGÍA DE LA EXTRACCIÓN, PREPARACIÓN EN BANCO Y TRASPLANTE RENAL SOBRE CADÁVER PRESERVADO SEGÚN TÉCNICA DE W. THIEL Y SIMULADORES

GONZALEZ ENGUITA CARMEN

CURSOS/ACTIVIDADES FORMATIVAS

4772/015

12A EDICIÓN TXTHIEL 2024: CURSO AVANZADO EN CIRUGÍA DE DONACIÓN Y TRASPLANTE RENAL: FUNDAMENTOS Y TÉCNICAS QUIRÚRGICAS EN CIRUGÍA DE EXTRACCIÓN, DE BANCO E IMPLANTE RENAL SOBRE CADÁVER PRESERVADO SEGÚN TÉCNICA DE W. THIEL Y SIMULADORES ANATÓMICOS

GONZALEZ ENGUITA CARMEN

CURSOS/ACTIVIDADES FORMATIVAS

4772/013

SERVICIO DE UROLOGÍA HUFJD

GONZALEZ ENGUITA CARMEN

OTRAS ACTIVIDADES DE INVESTIGACION

Clinical trials

The clinical trials listed below were in the recruitment phase in 2023. If you are interested in participating in any of the currently open trials, more information is available on the website (https://ensayos.quironsalud.es/)

EudraCT Number

TITLE

PHASE

MC1

INT2

PRINCIPAL RESEARCHER

2016-004017-27

QUIMIOTERAPIA NEOADYUVANTE VERSUS ADYUVANTE EN CARCINOMA UROTELIAL DEL TRACTO URINARIO SUPERIOR. ENSAYO CLÍNICO RANDOMIZADO DE VIABILIDAD FASE II (URANUS)

II

SI

NO

BUENDIA GONZALEZ ELENA

2017-002928-24

TRATAMIENTO DE LOS TUMORES VESICALES NO MÚSCULO INFILTRANTE DE ALTO RIESGO CON IMUNO BCG MOREAU RJ COMO PROFILAXIS DE RECIDIVA Y PROGRESIÓN

II

SI

NO

MONZO GARDINER JUAN IGNACIO

2018-004273-27

ENSAYO CLÍNICO MULTICÉNTRICO CON PRODUCTO SANITARIO ASOCIADO A FÁRMACO EN USO TERAPEUTICO AUTORIZADO PARA EL TRATAMIENTO DE CVNMI EVALUANDO LA EFICACIA Y TOLERABILIDAD DEL TRATAMIENTO ADYUVANTE CON EMDA-MMC VERSUS ESTÁNDAR BCG Y LA EFICACIA DEL BIO-MARCADOR URINARIO MCM5 ADXBLADDER® EN LA DETECCIÓN DE RECIDIVA TUMORAL EN PACIENTES CON CVNMI DE ALTO GRADO

II

SI

SI

MONZO GARDINER JUAN IGNACIO

2019-003618-15

ESTUDIO ABIERTO, DE UN SOLO BRAZO, DE CONTINUACIÓN DE TRATAMIENTO CON DAROLUTAMIDA A PACIENTES INCLUIDOS PREVIAMENTE EN ESTUDIOS PROMOVIDOS POR BAYER

III

SI

SI

GONZALEZ ENGUITA CARMEN

2017-004512-19

ALBAN: UN ENSAYO DE FASE III, ALEATORIZADO Y ABIERTO, QUE EVALUA LA EFICACIA DEL ATEZOLIZUMAB ADMINISTRADO DE FORMA CONCOMITANTE CON INSTILACIONES VESICALES DE BCG (BACILO DE CALMETTE-GUERIN) DURANTE UN AÑO EN PACIENTES CON CANCER DE VEJIGA SIN INVASION MUSCULAR CON ALTO RIESGO DE RECIDIVA Y QUE NO HAN SIDO TRATADOS PREVIAMENTE CON BCG

III

SI

SI

MONZO GARDINER JUAN IGNACIO

2021-005948-29

ESTUDIO FASE 3, MULTICENTRICO, CON UN UNICO GRUPO, PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE UGN-102 COMO TRATAMIENTO QUIMIOABLATIVO PRINCIPAL EN PACIENTES CON CANCER DE VEJIGA SIN INVASION MUSCULAR (CVSIM) DE EVOLUCION LENTA (EL) Y RIESGO INTERMEDIO (RI) DE RECURRENCIA - (BL011)

III

SI

SI

MONZO GARDINER JUAN IGNACIO

2022-001236-28

ESTUDIO DE FASE III CON UN SOLO GRUPO PARA EVALUAR LA EFICACIA Y LA SEGURIDAD DE ONCOFID-P-B (CONJUGADO PACLITAXEL-ACIDO HIALURONICO) ADMINISTRADO POR VIA INTRAVESICAL A PACIENTES CON CARCINOMA IN SITU DE VEJIGA SIN RESPUESTA A BCG, CON O SIN ENFERMEDAD PAPILAR TA-T1

III

SI

SI

MONZO GARDINER JUAN IGNACIO

2014-001930-26

ENSAYO CLÍNICO ALEATORIZADO, ENMASCARADO PARA EL EVALUADOR, PARA EVALUAR LA EFICACIA DE CUATRO PAUTAS ANALGÉSICAS EN PACIENTES SOMETIDOS A LITOTRICIA EXTRACORPÓREA CON ONDAS DE CHOQUE (LEOC)

IV

NO

NO

BUENO SERRANO GONZALO

2022-501246-30-00

ESTUDIO POST-AUTORIZACION, MULTICENTRICO, DOBLE CIEGO, ALEATORIZADO, CONTRLADO CON PLACEBO, CRUZADO DE DOS VIAS PARA EVALUAR LA EFICACIA DE DARIDOREXANT EN PACIENTES CON INSOMNIO Y NICTURIA ASOCIADA

IV

SI

SI

GARDE GARCIA HECTOR

NA

ENSAYO CLÍNICO ALEATORIZADO, ABIERTO, CONTROLADO, PARA EVALUAR LA EFICACIA DE UN PRODUCTO COMPUESTO POR D MANOSA + CRANMAX + VITAMINA D3 (UROMANNOSA®) EN MUJERES CON INFECCIONES URINARIAS DE REPETICION DEL TRACTO URINARIO INFERIOR

N/A

SI

NO

GONZALEZ ENGUITA CARMEN

MC1: Multicéntrico INT2: Internacional